FlyBase Allele Report: Dmel\Xbp1[d08698]

(Cheng and Chiang, 2018, Wang et al., 2015, Wang et al., 2014, Casas-Tinto et al., 2011, Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^2xAPP.SP.UAS

(Casas-Tinto et al., 2011)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Cheng and Chiang, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2014)

Phenotype Manifest In

midgut | adult stage, with Scer\GAL4^NP5130

(Wang et al., 2014)

midgut | adult stage | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2014)

Detailed Description

Statement

Reference

The expression throughout development of Xbp1^d08698 under the control of Scer\GAL4^NP5130 leads to a significant decrease in the proportion of mitotic cell in the midguts of 25- to 55-days old adults, as compared to controls; expression under the control of Scer\GAL4^unspecified in adult midgut clones results in a significant decrease in clone cell number at 7 days after clone induction, as compared to control clones.

(Wang et al., 2014)

Expression of Xbp1^d08698 in the developing eye under the control of Scer\GAL4^GMR.PF has no effect on eye development.

(Casas-Tinto et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Xbp1^d08698 is a suppressor of abnormal eye color phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Xbp1^d08698, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Xbp1^d08698, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Xbp1^d08698, Scer\GAL4^GMR.PF is a suppressor of photoreceptor neuron phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Xbp1^d08698, Scer\GAL4^GMR.PF is a suppressor of eye | progressive phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\APP^{2xAPP.SP.Scer\UAS} and Xbp1^d08698 in the developing eye under the control of Scer\GAL4^GMR.PF significantly improves both eye organisation and size compared to expression of Hsap\APP^{2xAPP.SP.Scer\UAS} alone.

Hsap\APP^{2xAPP.SP.Scer\UAS} flies co-expressing either Xbp1^d08698 in the developing eye (under the control of Scer\GAL4^GMR.PF) show milder degenerative changes in the retina compared to flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS}, indicating Xbp1 protects against the progressive degeneration of photoreceptors induced by Hsap\APP.

(Casas-Tinto et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

XBP1^d08698

(Cheng and Chiang, 2018)

Xbp1^d08698

(Wang et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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