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General Information
Symbol
Dmel\InRUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0284595
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-InR
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of InR.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of InRUAS.cUa under the control of the split-GAL4 pair of Scer\GAL4DBD.AkhR and Hsap\RELAAD.nSyb in adult females results in a delay in starvation-induced hyperactivity, compared to controls.

The temporally regulated expression (by Gal80[ts]) of InRUAS.cUa, for 4 or 14 days under the control of Scer\GAL4NP5130, leads to a strong increase in the proportion of mitotic cells in the adult midgut, as compared to controls.

Expression of InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF results in substantial overgrowth and disorganisation in the eye, as reflected by loss of ommatidial structure and bristle pattern.

Overexpression of InRScer\UAS.cUa in the mushroom bodies, under the control of Scer\GAL4ey-OK107 increases the number of mushroom body neurons by 33%. There is a disproportional enlargement of the γ lobe, suggesting InRScer\UAS.cUa overexpression causes enhanced cycling in the early larval instar stage, when proliferation rates are normally low.

Expression of InRScer\UAS.cUa under the control of Scer\GAL4kirre.PU does not affect somatic muscle pattern in embryos. The size of the segmental border muscle and the DA1 muscle and also the number of nuclei present in these muscles are normal.

Expression of InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF results in severe overgrowth of the eye.

Expression of InRUAS.cUa in larvae under the control of Scer\GAL4repo results in a thickened optic stalk due to increased numbers of glial cells; there is little or no overmigration of glial cells along the Bolwig nerve, compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The increased proportion of mitotic adult midgut cells resulting from the temporally regulated expression (by Gal80[ts]) of InRUAS.cUa, for 4 or 14 days under the control of Scer\GAL4NP5130, is partially suppressed by the co-expression of Xbp1UAS.RB.

Co-expression of Ptp61FScer\UAS.m.T:Hsap\MYC partially suppresses the eye overgrowth phenotype caused by expression of InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

Co-expression of Ptp61FScer\UAS.n.T:Hsap\MYC completely suppresses the eye overgrowth phenotype caused by expression of InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

Co-expression of Ptp61FScer\UAS.m.T:Hsap\MYC partially suppresses the eye overgrowth phenotype caused by expression of InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

Co-expression of dockScer\UAS.cRa does not suppress the eye overgrowth phenotype caused by expression of InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

Co-expression of dockScer\UAS.cRa results in a further reduction in eye overgrowth in flies co-expressing both Ptp61FScer\UAS.m.T:Hsap\MYC and InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference

The additional co-expression of InRScer\UAS.cUa enhances the fully penetrant rough eye phenotype that results from the co-expression of HPV18\E6Scer\UAS.T:Hsap\MYC and Hsap\UBE3AScer\UAS.cRa under the control of Scer\GAL4GMR.PU, leading to overgrowth and out-pocketing of the eye tissue.

The age-progressive memory induced by expression of Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav.PU is enhanced by co-expression of InRScer\UAS.cUa : the memory defect are detectable even in young 5-day-old flies that perform normally in the aversive olfactory memory assay when expressing Hsap\APPAβ1-42.Scer\UAS.cIa alone.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
InRScer\UAS.cUa
InRUAS.cUa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Unknown
Secondary FlyBase IDs
    References (13)