FB2026_02 , released June 18, 2026
Allele: Dmel\Ptp61FUAS.n.Tag:MYC
Open Close
General Information
Symbol
Dmel\Ptp61FUAS.n.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0284952
Feature type
allele
Associated gene
Dmel\Ptp61F
Associated Insertion(s)
Carried in Construct
P{UAS-Myc-Ptp61F.n}
Key Links
Transgenic product class
wild_type
(Buszard et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Buszard et al., 2013)
Mutagen
in vitro construct
(Buszard et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Myc-Ptp61F.n}
Cytology
Description

UASt regulatory sequences drive expression of the Ptp61F n isoform (nucleus-localised form), which is tagged at the N-terminal end with three copies of Tag:MYC.

(Buszard et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ptp61F
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ptp61FScer\UAS.n.T:Hsap\MYC under the control of Scer\GAL4GMR.PF disrupts interommatidial bristle pattern and results in a mild rough-eye phenotype.

      Expression of Ptp61FScer\UAS.n.T:Hsap\MYC under the control of Scer\GAL4dpp.PU results in a reduction in area of the 1st posterior cell of the wing to approximately 70% of that in controls. The reduction in area is due to a decrease both in cell size and in cell number.

      Expression of Ptp61FScer\UAS.n.T:Hsap\MYC under the control of Scer\GAL4ey.PH reduces cell proliferation in the eye disc (as assayed by BrdU incorporation), without affecting cell differentiation or apoptosis.

      (Buszard et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      Ptp61FUAS.n.Tag:MYC, Scer\GAL4GMR.PF is a suppressor of visible phenotype of InRUAS.cUa, Scer\GAL4GMR.PF

      (Buszard et al., 2013)
      NOT Suppressor of
      Statement
      Reference

      Ptp61FUAS.n.Tag:MYC, Scer\GAL4GMR.PF is a non-suppressor of visible phenotype of Pi3K92EUAS.Tag:MYC, Scer\GAL4GMR.PF

      (Buszard et al., 2013)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Ptp61FUAS.n.Tag:MYC, Scer\GAL4GMR.PF is a non-enhancer of eye phenotype of Pi3K92EUAS.Tag:MYC, Scer\GAL4GMR.PF

      (Buszard et al., 2013)
      Suppressor of
      Statement
      Reference

      Ptp61FUAS.n.Tag:MYC, Scer\GAL4GMR.PF is a suppressor of eye phenotype of InRUAS.cUa, Scer\GAL4GMR.PF

      (Buszard et al., 2013)
      NOT Suppressor of
      Statement
      Reference

      Ptp61FUAS.n.Tag:MYC, Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Pi3K92EUAS.Tag:MYC, Scer\GAL4GMR.PF

      (Buszard et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Ptp61FScer\UAS.n.T:Hsap\MYC completely suppresses the eye overgrowth phenotype caused by expression of InRScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

      Co-expression of Ptp61FScer\UAS.n.T:Hsap\MYC has no overt effect on the eye overgrowth phenotype caused by expression of Pi3K92EScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF.

      (Buszard et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Ptp61FUAS.m.Tag:MYC, Scer\GAL4arm.PU, Ptp61FUAS.n.Tag:MYC rescues Ptp61FΔ

      (Buszard et al., 2013)
      Partially rescues

      Scer\GAL4arm.PU/Ptp61FUAS.n.Tag:MYC partially rescues Ptp61FΔ

      (Buszard et al., 2013)
      Comments

      Expression of Ptp61FScer\UAS.n.T:Hsap\MYC under the control of Scer\GAL4arm.PU fails to rescue the reduced lifespan of Ptp61FΔ flies. The reduced fecundity of Ptp61FΔ females is partially rescued.

      Simultaneous co-expression of Ptp61FScer\UAS.m.T:Hsap\MYC and Ptp61FScer\UAS.n.T:Hsap\MYC under the control of Scer\GAL4arm.PU rescues the reduced lifespan of Ptp61FΔ flies. The reduced fecundity of Ptp61FΔ females is also largely rescued.

      (Buszard et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ptp61FScer\UAS.n.T:Hsap\MYC
      Ptp61FUAS.n.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)