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General Information
Symbol
Dmel\AhcyL1HM05009
Species
D. melanogaster
Name
FlyBase ID
FBal0239341
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of AhcyL1HM05009 driven by Scer\GAL4Act5C.Switch.PR (in males fed RU486 during adulthood, to avoid developmental effects) significantly extends lifespan compared to controls; at 40 days old, age-dependent decline in climbing ability (seen in controls) is significantly suppressed in RU486-fed males and age-dependent decreases in fecundity (seen in controls, measured as number of eggs laid per day) is significantly suppressed in RU486-fed females. There are no significant differences in survival of RU486-fed Scer\GAL4Act5C.Switch.PR>AhcyL1HM05009 flies with addition of paraquat to food, compared to controls (no increased ability to withstand oxidative stress). Expression of AhcyL1HM05009 driven simultaneously by Scer\GAL4bun-Switch1.32 and Scer\GAL4Switch1.106 (in males or females fed RU486 during adulthood) does not significantly affect life span compared to controls; when expression is driven by Scer\GAL4elav.Switch.PO or Scer\GAL4TIGS-2, there is a significant extension of lifespan in RU486-fed males and females. Dietary restriction (reduced sugar and yeast in food) significantly increases lifespan; in Scer\GAL4Act5C.Switch.PR>AhcyL1HM05009 flies, dietary restriction does not additionally extend lifespan.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
AhcyL1HM05009
CG9977HM05009
Name Synonyms
Secondary FlyBase IDs
    References (3)