FB2025_05 , released December 11, 2025
Allele: Scer\GAL4TIGS-2
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General Information
Symbol
Scer\GAL4TIGS-2
Species
S. cerevisiae
Name
FlyBase ID
FBal0241122
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{Switch-unk}TIGS-2
Carried in Construct
Also Known As
TIGS-2, TIGS, GS-TIGS-GAL4
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{Switch-unk}TIGS-2
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{Switch-unk}
    Encoded product / tool
    GAL4::GS
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        third instar larval stage
        embryonic/larval fat body
        (Yamashita et al., 2021)
        larval digestive system
        (Yamashita et al., 2021)
        pupal stage -- adult stage
        adult digestive system
        (Rera et al., 2011)
        adult stage
        adult digestive system
        (Poirier et al., 2008)
        adult midgut
        (Filer et al., 2017)
        adult gut
        (Yamashita et al., 2021)
        Additional Information
        Statement
        Reference

        Drives mifepristone-inducible expression in the larval, pupal, and adult digestive system, and in the larval fat body.

        (FlyBase Curators, 2017)

        ScerGAL4TIGS-2 drives expression in the digestive tract, but not in the fat body.

        (Rera et al., 2011)

        ScerGAL4TIGS-2 drives mifepristone-inducible expression in the pupal/adult digestive system.

        (Poirier et al., 2008)
         
        Marker for
        adult digestive system
        (Rera et al., 2011)
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        Scer\GAL4TIGS-2, pntP1.UAS has short lived phenotype, enhanceable by Scer\GAL4TIGS-2/foxoUAS.cFa

        (Alic et al., 2014)
        Suppressed by
        Enhancer of
        Statement
        Reference

        Scer\GAL4TIGS-2/foxoUAS.cFa is an enhancer of short lived phenotype of Scer\GAL4TIGS-2, pntP1.UAS

        (Alic et al., 2014)
        Suppressor of
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        The Scer\GAL4TIGS-2 driver shows no evidence of leakiness during the embryonic, larval or pupal stages (it does not drive expression of a UAS transgene in the absence of RU486 during these stages).

        (Poirier et al., 2008)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Scer\GAL4TIGS-2
        Name Synonyms
        Secondary FlyBase IDs
          References (25)