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Citation
Rera, M., Bahadorani, S., Cho, J., Koehler, C.L., Ulgherait, M., Hur, J.H., Ansari, W.S., Lo, T., Jones, D.L., Walker, D.W. (2011). Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog.  Cell Metab. 14(5): 623--634.
FlyBase ID
FBrf0216555
Publication Type
Research paper
Abstract

In mammals, the PGC-1 transcriptional coactivators are key regulators of energy metabolism, including mitochondrial biogenesis and respiration, which have been implicated in numerous pathogenic conditions, including neurodegeneration and cardiomyopathy. Here, we show that overexpression of the Drosophila PGC-1 homolog (dPGC-1/spargel) is sufficient to increase mitochondrial activity. Moreover, tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract extends life span. Long-lived flies overexpressing dPGC-1 display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homeostasis in old flies. Together, these results demonstrate that dPGC-1 can slow aging both at the level of cellular changes in an individual tissue and also at the organismal level by extending life span. Our findings point to the possibility that alterations in PGC-1 activity in high-turnover tissues, such as the intestine, may be an important determinant of longevity in mammals.

PubMed ID
PubMed Central ID
PMC3238792 (PMC) (EuropePMC)
Related Publication(s)
Note

A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life.
Zhou et al., 2011, Cell Metab. 14(5): 571--572 [FBrf0216623]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Metab.
    Title
    Cell Metabolism
    Publication Year
    2005-
    ISBN/ISSN
    1550-4131
    Data From Reference