FlyBase Gene Report: Dmel\MT:DNA

General Information

Symbol

Dmel\MT:DNA

Species

D. melanogaster

Name

Mitochondrial DNA

Annotation Symbol

Feature Type

mitochondrial_sequence

FlyBase ID

FBgn0013298

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

mtDNA

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MT:DNA using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\MT:DNA in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\MT:DNA

View exonic expression by tissue for Dmel\MT:DNA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of MT:DNA

Transgenic constructs containing regulatory region of MT:DNA

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:MT:DNA. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

mitochondrial_sequence

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (0)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Temperature-dependent selection in mtDNA transmission is co-operatively regulated by gene products that are encoded by the X, second and third chromosomes.

(Doi et al., 1999)

The 4.6kb A+T rich region of D.melanogaster MT:DNA has been cloned and sequenced.

(Lewis et al., 1994)

The level of MT:DNA remains fairly constant throughout the life span of D.melanogaster, being approximately 1% of the total DNA at all ages.

(Calleja et al., 1993)

MT:DNA transmission in the heteroplasmic state is selective and temperature-dependent.

(Matsuura et al., 1993)

Transmission of two types of MT:DNA are examined at 19^oC and 25^oC using heteroplasmic lines. Results demonstrate selective transmission of one type of MT:DNA depends on the temperature at which the heteroplasmic lines are maintained.

(Matsuura et al., 1991)

The temperature-dependency of total electron-transport activity of mitochondria encoded by both MT:DNA and Dmau\MT:DNA does not differ from that of mitochondria encoded by MT:DNA alone. For the selective transmission of mitochondrial DNA in the heteroplasmic state the temperature-dependency of the mitochondrial respiratory function does not appear to play a major role as a selective force.

(Nagata and Matsuura, 1991)

Temperature-dependent transmission of mitochondrial DNA is investigated in heteroplasmic lines of D.melanogaster established by germ-plasm transplantation. Results suggest that both the nuclear and two types of mitochondrial genomes are involved in the selective transmission of mtDNA. Selection transmission of mtDNA in heteroplasmic lines depends on temperature in all cases of intra- and interspecific combinations.

(Tsujimoto et al., 1991)

A very rapid response in the induction of the α-regulatory subunit of the mitochondrial F₁-ATPase complex is observed in 37^oC heat shocked larvae.

(Luis et al., 1990)

Mitochondrial genes all have the prefix mt:. Data for individual mt genes will be found under the relevant records. This record includes only those data that cannot be conveniently assigned to a particular mt gene, and some general references. The complete D.melanogaster mtDNA sequence is 19,517-bp (Accession number U37541).

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

MT:DNA

(Chen et al., 2019)

MtDNA

(Kann et al., 1998)

mitochondrial DNA

(Anderson et al., 2022)

mtDNA

(Keaney et al., 2020, Keaney et al., 2020, Chen et al., 2019, Drummond et al., 2019, Kristensen et al., 2019, Mengel-From et al., 2019, Montooth et al., 2019, Mossman et al., 2019, Ciesielski et al., 2018, Ren et al., 2017, Kandul et al., 2016, Chen et al., 2014, Dokianakis and Ladoukakis, 2014, Martínez-Azorín et al., 2013, Pichaud et al., 2013, Pimenta de Castro et al., 2012, Rand, 2011, Rera et al., 2011, Valenzuela, 2011, Hao et al., 2010, Nunes et al., 2010, Valenzuela, 2010, Morel et al., 2008, Rand et al., 2007, Schlötterer and Nunes, 2007, Park et al., 2006, Wagaman et al., 2006, Yui and Matsuura, 2006, Wagaman et al., 2004, Cohen et al., 2003, Roberti et al., 2003, Ballard et al., 2002, Mitrofanov et al., 2002, Tsujino et al., 2002, Maier et al., 2001, Rand et al., 2001, Ballard, 2000, Rand et al., 1998, Ballard et al., 1996, Kilpatrick and Rand, 1995, Lewis et al., 1994, Calleja et al., 1993, Crandall and Templeton, 1993, Matsuura et al., 1993, Hale and Singh, 1991, Hale and Singh, 1991, Matsuura et al., 1991, Nagata and Matsuura, 1991, Tsujimoto et al., 1991, Gonzalez et al., 1990, Matsuura et al., 1990, Tourmente et al., 1990)

Name Synonyms

Mitochondrial DNA

mitochondrial DNA

(Camus and Dowling, 2018)

mitochondrial genome

(Wolff et al., 2016)

Secondary FlyBase IDs

FBgn0003457

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 6 )

Sequence Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

References (314)

NA

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