FlyBase Allele Report: Dmel\ph-p[505]

General Information

Symbol

Dmel\ph-p⁵⁰⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0098672

Feature type

allele

Associated gene

Dmel\ph-p

Associated Insertion(s)

Carried in Construct

Also Known As

ph⁵⁰⁵, ph⁰

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Shao et al., 1999)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q749term.

(Feng et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:2,129,367..2,129,367 [-]

Nucleotide change:

C2129367T

Amino acid change:

Q759term | ph-p-PA; Q516term | ph-p-PB; Q516term | ph-p-PC; Q516term | ph-p-PD

Reported amino acid change:

Q749term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. There Gln749 mutation location appears to be a typo, since there is no Gln at that location in the reference strain. The mutation was mapped to Gln759, which is in the correct region relative to the map in FBrf0214189. The mutant strain carries two nonsense mutations, one in Gln398 of ph-d and one reported at Gln749 of ph-p.

(Feng et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with ph-d⁵⁰⁵

(Jiang et al., 2018, Classen et al., 2009)

model of carcinoma

CEA with ph-d⁵⁰⁵

(Beira et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has visible | somatic clone phenotype

(Feng et al., 2011)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has lethal | embryonic stage phenotype

(Feng et al., 2011)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has neoplasia | somatic clone phenotype

(Classen et al., 2009)

Phenotype Manifest In

Other

Statement

Reference

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has eye disc | somatic clone phenotype

(Feng et al., 2011, Classen et al., 2009)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has eye | somatic clone phenotype

(Feng et al., 2011)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has wing phenotype

(Randsholt et al., 2000)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has leg | ectopic phenotype

(Randsholt et al., 2000)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has wing vein | ectopic phenotype

(Randsholt et al., 2000)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has leg phenotype

(Randsholt et al., 2000)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has wing | anterior phenotype

(Randsholt et al., 2000)

ph-d⁵⁰⁵, ph-p⁵⁰⁵ has ventral denticle belt phenotype

(Shao et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

ph-d⁵⁰⁵ ph-p⁵⁰⁵ hemizygous males die as embryos, soon after germ band retraction has finished.

ph-d⁵⁰⁵ ph-p⁵⁰⁵ mutant clones in mosaic eye discs overproliferate. The effect of the clones is both autonomous and non-autonomous.

(Feng et al., 2011)

Imaginal discs composed predominantly of ph-d⁵⁰⁵ ph-p⁵⁰⁵ cells (generated using the FLP/cell-lethal method) are strongly overgrown. The mutant tissue shows defects in epithelial organisation and differentiation.

(Classen et al., 2009)

Irradiated ph-p⁵⁰⁵/+. ph-d⁵⁰⁵/+ animals show vein duplications in anterior territories and vesicles of tissue trapped between the wing surfaces in both anterior and posterior compartments of the wing. they also exhibit abnormal anterior wing margins, and bifurcated anterior wing compartments. Pattern bifurcation and duplication are also seen in the leg, associated with trapped vesicles within the leg.

(Randsholt et al., 2000)

ph-p⁵⁰⁵, ph-d⁵⁰⁵ mutant embryos lack ventral denticle belts.

(Shao et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

ph-p⁵⁰⁵ is partially rescued by ph-p^Tag:FLAG

(Shao et al., 1999)

Comments

Embryos carrying a single copy of P{Pc-ph-p.FLAG} show partially restored denticle belts. Some embryos carrying two copies show fully restored denticle belts.

(Shao et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Associated with: ph-d⁵⁰⁵.

(Feng et al., 2011)

Induced with: ph-d⁵⁰⁵.

(Shao et al., 1999)

The "ph[505]" chromosome has mutations in both ph-p and ph-d.

(Feng et al., 2011)

Comments

The ph-d⁵⁰⁵ chromosome is null for both ph-d and ph-p.

(Shao et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ph-p⁵⁰⁵

ph⁰

(Chanas et al., 2004, Perrin et al., 2003, Randsholt et al., 2000)

ph⁵⁰⁵

(Beira et al., 2018, Jiang et al., 2018, Torres et al., 2018, Feng et al., 2011, Chanas and Maschat, 2005, Chanas et al., 2004, Randsholt et al., 2000, Shao et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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