FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term cytokine-mediated signaling pathway ID (Ontology) GO:0019221 (Gene Ontology)
Definition The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.[ PubMed:19295629 ]
Also Known As "cytokine and chemokine mediated signaling pathway" ; "cytokine mediated signalling pathway"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 cytokine-mediated signaling pathway (all annotations which use CV term, excluding "NOT" statements)       5
     involved_in | cytokine-mediated signaling pathway       5
Spanning Tree (Parents/Children)
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signal transduction
 |__cell surface receptor signaling pathway__
response to cytokine                         |
 |__cellular response to cytokine stimulus___|
                                             cytokine-mediated signaling pathway  36 rec.
                                              |__adiponectin-activated signaling pathway 1 rec.
                                              |__chemokine-mediated signaling pathway
                                              |   |__C-C chemokine receptor CCR2 signaling pathway(+)
                                              |   |__C-C chemokine receptor CCR4 signaling pathway(+)
                                              |   |__C-C chemokine receptor CCR7 signaling pathway(+)
                                              |   |__C-X-C chemokine receptor CXCR4 signaling pathway(+)
                                              |   |__chemokine (C-C motif) ligand 2 signaling pathway(+)
                                              |   |__chemokine (C-C motif) ligand 5 signaling pathway
                                              |   |__chemokine (C-C motif) ligand 19 signaling pathway(+)
                                              |   |__chemokine (C-C motif) ligand 21 signaling pathway(+)
                                              |   |__chemokine (C-X-C motif) ligand 12 signaling pathway(+)
                                              |   |__regulation of chemokine-mediated signaling pathway(+)
                                              |   |__thrombopoietin-mediated signaling pathway
                                              |__ciliary neurotrophic factor-mediated signaling pathway
                                              |__erythropoietin-mediated signaling pathway
                                              |__granulocyte colony-stimulating factor signaling pathway 1 rec.
                                              |__granulocyte-macrophage colony-stimulating factor signaling pathway
                                              |__interferon-mediated signaling pathway
                                              |   |__type I interferon-mediated signaling pathway(+)
                                              |   |__type II interferon-mediated signaling pathway(+)
                                              |   |__type III interferon-mediated signaling pathway
                                              |__interleukin-1-mediated signaling pathway
                                              |   |__regulation of interleukin-1-mediated signaling pathway(+)
                                              |__interleukin-2-mediated signaling pathway
                                              |   |__regulation of interleukin-2-mediated signaling pathway(+)
                                              |__interleukin-3-mediated signaling pathway
                                              |__interleukin-4-mediated signaling pathway
                                              |   |__regulation of interleukin-4-mediated signaling pathway(+)
                                              |__interleukin-5-mediated signaling pathway
                                              |__interleukin-6-mediated signaling pathway
                                              |   |__regulation of interleukin-6-mediated signaling pathway(+)
                                              |__interleukin-7-mediated signaling pathway
                                              |__interleukin-8-mediated signaling pathway
                                              |__interleukin-9-mediated signaling pathway
                                              |__interleukin-10-mediated signaling pathway
                                              |__interleukin-11-mediated signaling pathway
                                              |__interleukin-12-mediated signaling pathway
                                              |__interleukin-13-mediated signaling pathway
                                              |__interleukin-15-mediated signaling pathway
                                              |__interleukin-17-mediated signaling pathway
                                              |   |__regulation of interleukin-17-mediated signaling pathway(+)
                                              |__interleukin-17A-mediated signaling pathway
                                              |__interleukin-18-mediated signaling pathway
                                              |   |__regulation of interleukin-18-mediated signaling pathway(+)
                                              |__interleukin-19-mediated signaling pathway
                                              |__interleukin-20-mediated signaling pathway
                                              |__interleukin-21-mediated signaling pathway
                                              |__interleukin-22-mediated signaling pathway
                                              |__interleukin-23-mediated signaling pathway
                                              |__interleukin-27-mediated signaling pathway
                                              |   |__regulation of interleukin-27-mediated signaling pathway(+)
                                              |__interleukin-32-mediated signaling pathway
                                              |__interleukin-33-mediated signaling pathway
                                              |__interleukin-34-mediated signaling pathway
                                              |__interleukin-35-mediated signaling pathway
                                              |   |__regulation of interleukin-35-mediated signaling pathway(+)
                                              |__Kit signaling pathway
                                              |   |__regulation of Kit signaling pathway(+)
                                              |__leptin-mediated signaling pathway
                                              |   |__negative regulation of appetite by leptin-mediated signaling pathway
                                              |__macrophage colony-stimulating factor signaling pathway
                                              |   |__regulation of macrophage colony-stimulating factor signaling pathway(+)
                                              |__macrophage migration inhibitory factor signaling pathway
                                              |   |__regulation of macrophage migration inhibitory factor signaling pathway(+)
                                              |__oncostatin-M-mediated signaling pathway
                                              |__prolactin signaling pathway
                                              |   |__regulation of prolactin signaling pathway(+)
                                              |__regulation of cytokine-mediated signaling pathway 14 rec.
                                              |   |__negative regulation of cytokine-mediated signaling pathway(+) 6 rec.
                                              |   |__positive regulation of cytokine-mediated signaling pathway(+) 8 rec.
                                              |   |__regulation of chemokine-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-1-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-2-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-4-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-6-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-17-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-18-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-27-mediated signaling pathway(+)
                                              |   |__regulation of interleukin-35-mediated signaling pathway(+)
                                              |   |__regulation of Kit signaling pathway(+)
                                              |   |__regulation of macrophage colony-stimulating factor signaling pathway(+)
                                              |   |__regulation of macrophage migration inhibitory factor signaling pathway(+)
                                              |   |__regulation of prolactin signaling pathway(+)
                                              |   |__regulation of tumor necrosis factor-mediated signaling pathway(+) 14 rec.
                                              |   |__regulation of type I interferon-mediated signaling pathway(+)
                                              |   |__regulation of type II interferon-mediated signaling pathway(+)
                                              |__tumor necrosis factor-mediated signaling pathway 29 rec.
                                                  |__regulation of tumor necrosis factor-mediated signaling pathway(+) 14 rec.
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Is a cell surface receptor signaling pathway
Part of cellular response to cytokine stimulus
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Synonyms
  • "cytokine and chemokine mediated signaling pathway" EXACT
    "cytokine mediated signalling pathway" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-449147 "Signaling by Interleukins"
Reactome:R-HSA-913531 "Interferon Signaling"
Reactome:R-HSA-9607240 "FLT3 Signaling"
Reactome:R-HSA-9674555 "Signaling by CSF3 (G-CSF)"
Reactome:R-HSA-9680350 "Signaling by CSF1 (M-CSF) in myeloid cells"