FlyBase Allele Report: Dmel\Socs36E[EY11]

General Information

Symbol

Dmel\Socs36E^EY11

Species

D. melanogaster

Name

FlyBase ID

FBal0240355

Feature type

allele

Associated gene

Dmel\Socs36E

Associated Insertion(s)

P{?EPgy2}Socs36E^EY11

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Monahan and Starz-Gaiano, 2013)

loss of function allele

(Almudi et al., 2009)

Mutagen

Delta2-3 transposase

(Almudi et al., 2009)

Progenitor genotype

P{EPgy2}Socs36E^EY06665

(Almudi et al., 2009)

Associated Insertion(s)

P{?EPgy2}Socs36E^EY11

Cytology

Description

Imprecise excision of the progenitor insertion, such that 500bp of the original element remain.

(Almudi et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:18,142,011..18,142,011

(Almudi et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA with Egfr^UAS.cBa

(Herranz et al., 2012)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Herranz et al., 2012)

viable

(Almudi et al., 2009)

visible

(Almudi et al., 2009)

visible | adult stage

(Herranz et al., 2012)

Phenotype Manifest In

eye

(Almudi et al., 2009)

photoreceptor cell R7 | increased number

(Almudi et al., 2009)

photoreceptor cell R7 | increased number (with Df(2L)Exel7070)

(Almudi et al., 2009)

wing

(Herranz et al., 2012)

Detailed Description

Statement

Reference

Socs36E^EY11/Socs36E^EY11 flies have significantly larger wings than wild-type controls.

(Herranz et al., 2012)

Socs36E^EY11 flies have rough eyes. Extra photoreceptor R7 cells are present in 2% of ommatidia.

Socs36E^EY11/Df(2L)Exel7070 flies have extra photoreceptor R7 cells are present in 2.7% of ommatidia.

(Almudi et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Socs36E^EY11/Socs36E^EY11 is an enhancer of abnormal size | third instar larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^hh.PU

(Herranz et al., 2012)

Other

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^hh.PU, Socs36E^EY11 has neoplasia | third instar larval stage phenotype

(Herranz et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Socs36E^EY11/Socs36E^EY11 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^hh.PU

(Herranz et al., 2012)

Suppressor of

Statement

Reference

Socs36E^EY11/Socs36E^EY11 is a suppressor | partially of photoreceptor cell R7 phenotype of sev^Δ22, sev¹⁴

(Almudi et al., 2009)

Other

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^hh.PU, Socs36E^EY11 has wing disc | third instar larval stage phenotype

(Herranz et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygosity for Socs36E^EY11 partially suppresses the loss of photoreceptor cells R7 seen in sev¹⁴ flies carrying sev^Δ22 (only 2% of ommatidia are missing the R7 cell in the double mutant flies).

(Almudi et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Socs36E^EY11

(Monahan and Starz-Gaiano, 2013, Herranz et al., 2012, Almudi et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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