FlyBase Allele Report: Dmel\sev[Δ22]

General Information

Symbol

Dmel\sev^Δ22

Species

D. melanogaster

Name

FlyBase ID

FBal0035590

Feature type

allele

Associated gene

Dmel\sev

Associated Insertion(s)

Carried in Construct

P{sev^Δ22}

Key Links

Transgenic product class

inframe_deletion

(Bohmann et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Bohmann et al., 1994)

Mutagen

in vitro construct

(Bohmann et al., 1994)

Progenitor genotype

Carried in construct

P{sev^Δ22}

Cytology

Description

Construct: Internal deletion in the extracellular domain.

(Bohmann et al., 1994)

Allele components

Component

Use(s)

Encoded product / tool

sev

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Bohmann et al., 1994)

Phenotype Manifest In

photoreceptor cell R7, with sev¹⁴

(Almudi et al., 2009)

Detailed Description

Statement

Reference

sev¹⁴ flies carrying sev^Δ22 lack R7 photoreceptor cells in 10% of ommatidia.

(Almudi et al., 2009)

Rescues the R7 phenotype of sev^- flies.

(Bohmann et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

sev^Δ22, sev¹⁴ has photoreceptor cell R7 phenotype, suppressible | partially by Socs36E^EY11/Socs36E^EY11

(Almudi et al., 2009)

Other

Statement

Reference

Jra^{bZIP.hs.sev.Tag:HA}, sev^Δ22 has photoreceptor cell R7 phenotype

(Bohmann et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygosity for Socs36E^EY11 partially suppresses the loss of photoreceptor cells R7 seen in sev¹⁴ flies carrying sev^Δ22 (only 2% of ommatidia are missing the R7 cell in the double mutant flies).

(Almudi et al., 2009)

sev^Δ22 in combination with Jra^{bZIP.hs.sev.T:Ivir\HA1} results in many missing R7 photoreceptors.

(Bohmann et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

sev^Δ22 rescues sev^unspecified

(Bohmann et al., 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

B. Dickson.

(Bohmann et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sev^Δ22

(Almudi et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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