FlyBase Allele Report: Dmel\sev[unspecified]

General Information

Symbol

Dmel\sev^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0051170

Feature type

allele

Associated gene

Dmel\sev

Associated Insertion(s)

Carried in Construct

Also Known As

unspecified

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Jukam et al., 2016)

Phenotype Manifest In

cone cell | ectopic

(Tomlinson et al., 2011)

photoreceptor cell R7

(Tomlinson et al., 2011, Wernet et al., 2003, Zuker et al., 1987)

photoreceptor cell R7 of pale ommatidium

(Wernet et al., 2006)

photoreceptor cell R8 of pale ommatidium

(Jukam et al., 2016)

photoreceptor cell R8 of yellow ommatidium

(Jukam et al., 2016)

photoreceptor cell R8 of yellow ommatidium | ectopic

(Wernet et al., 2006)

Detailed Description

Statement

Reference

Flies with sev^unspecified have a dramatically increased proportion of yellow R8 photoreceptors and a reciprocally decreased proportion of pale R8 photoreceptors.

(Jukam et al., 2016)

R7 precursor cells differentiate into cone cells in homozygous animals, resulting in adults with no photoreceptor R7 cells.

(Tomlinson et al., 2011)

Marker analysis indicates that pale ommatidium type R8 cells adopt a yellow ommatidium R8 cell fate in sev^unspecified homozygous eyes.

(Wernet et al., 2006)

The R8 cell of ommatidia of the dorsal rim area (DRA) of the eye develops normally in mutant animals. These flies lack all R7 cells.

(Wernet et al., 2003)

The eyelet has well developed rhabdomeres in mutant flies.

(Yasuyama and Meinertzhagen, 1999)

Displays locomotor activity rhythm with an approximately 24h period.

(Vosshall and Young, 1995)

Gap1^mip-w+ sev^unspecified flies have an excess of small rhabdomeres.

(Buckles et al., 1992)

Homozygotes lack the R7 photoreceptor cell.

(Zuker et al., 1987)

Pattern discrimination in sev^unspecified flies is similar to wild-type. The number of visits to pattern targets is less in sev^unspecified flies than wild-type. The reaction to the mid-point between two arranged targets is more in sev^unspecified flies than wild-type. sev^unspecified ort¹ double mutant flies show no pattern discrimination, but do show phototaxis to illuminated non-pattern targets.

(Mimura, 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

sev^unspecified has abnormal neuroanatomy | adult stage phenotype, suppressible by BEAF-32^AB-KO/BEAF-32^AB-KO

(Jukam et al., 2016)

NOT Suppressor of

Statement

Reference

sev^unspecified is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of BEAF-32^AB-KO

(Jukam et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

sev^unspecified has photoreceptor cell R8 of pale ommatidium phenotype, suppressible by BEAF-32^AB-KO/BEAF-32^AB-KO

(Jukam et al., 2016)

sev^unspecified has photoreceptor cell R8 of yellow ommatidium phenotype, suppressible by BEAF-32^AB-KO/BEAF-32^AB-KO

(Jukam et al., 2016)

sev^unspecified has phenotype, suppressible by rl^Su14

(Lim et al., 1999)

sev^unspecified has phenotype, suppressible by rl^Su23

(Lim et al., 1999)

NOT suppressed by

Statement

Reference

sev^unspecified has photoreceptor cell R8 of yellow ommatidium | ectopic phenotype, non-suppressible by ss^D115.7

(Wernet et al., 2006)

sev^unspecified has photoreceptor cell R7 of pale ommatidium phenotype, non-suppressible by ss^D115.7

(Wernet et al., 2006)

NOT Suppressor of

Statement

Reference

sev^unspecified is a non-suppressor of photoreceptor cell R8 of pale ommatidium phenotype of BEAF-32^AB-KO

(Jukam et al., 2016)

sev^unspecified is a non-suppressor of photoreceptor cell R8 of yellow ommatidium phenotype of BEAF-32^AB-KO

(Jukam et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Addition of BEAF-32^AB-KO/BEAF-32^AB-KO to flies with sev^unspecified suppresses the increased proportion of yellow R8 photoreceptors to the extent that it is reduced compared to controls and is similar to that seen in BEAF-32^AB-KO/BEAF-32^AB-KO animals without sev^unspecified.

(Jukam et al., 2016)

Transformation of pale ommatidium type R8 cells into yellow ommatidium type R8 cells in sev^unspecified homozygous is unaffected if the eyes are also ss^D115.7/ss^D115.7.

(Wernet et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

sev^unspecified is rescued by sev^αTub84B.PT

(Tomlinson et al., 2011)

sev^unspecified is rescued by sev^GMR.PT

(Tomlinson et al., 2011)

sev^unspecified is rescued by sev^Δ22

(Bohmann et al., 1994)

sev^unspecified is rescued by sev^+t16.3

(Hafen et al., 1987)

Not rescued by

sev^unspecified is not rescued by sev^mHYBRID1

(Bowtell et al., 1988)

Comments

Two copies of sev^αTub84B.PT fail to rescue the lack of R7 photoreceptor cells seen in sev^unspecified homozygotes. Four copies results in rescue of 29% of the R7 cells, while eight copies gives 100% rescue.

sev^GMR.PT rescues the lack of R7 photoreceptor cells seen in sev^unspecified homozygotes.

(Tomlinson et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sev^unspecified

unspecified

(Papatsenko et al., 1997, Vosshall and Young, 1995, Zuker et al., 1987, Mimura, 1982)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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