FlyBase Allele Report: Dmel\rl[Su14]

General Information

Symbol

Dmel\rl^Su14

Species

D. melanogaster

Name

FlyBase ID

FBal0051216

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Inoue and Glover, 1998, Sawamoto et al., 1996)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: G737A. Amino acid replacement: D185N. Mutation is in kinase subdomain VII.

(Lim et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:1,105,973..1,105,973 [+]

Nucleotide change:

G1105973A

Reported nucleotide change:

G737A

Amino acid change:

Reported amino acid change:

D185N

Comment:

Curator note: The site of the mutation was presented in the context of surrounding sequence and is correct, despite the fact that the reported and curated amino acid positions do not agree.

(Lim et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Lim et al., 1999)

Phenotype Manifest In

eye

(Lim et al., 1999)

eye photoreceptor cell

(Lim et al., 1999)

ommatidium

(Lim et al., 1999)

photoreceptor cell R7

(Sawamoto et al., 1996)

wing

(Lim et al., 1999)

wing vein

(Lim et al., 1999, Sawamoto et al., 1996)

Detailed Description

Statement

Reference

Heterozygotes do not have an apparent rough eye phenotype, but extra R7-like cells are seen in a fraction of the ommatidia. Homozygotes have a mild rough eye phenotype with multiple R7-like cells in most of the ommatidia. rl^Su14/rl¹ flies occasionally have extra wing vein material.

(Lim et al., 1999)

Supernumerary R7 cells and extra wing veins.

(Sawamoto et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

rl^Su14, tor^11D has some die during embryonic stage | dominant | maternal effect | maternal effect phenotype

(Lim et al., 1999)

Phenotype Manifest In

Suppressor of

Statement

Reference

rl^Su14 is a suppressor of phenotype of sev^unspecified

(Lim et al., 1999)

rl^Su14 is a suppressor of phenotype of Raf¹

(Lim et al., 1999)

rl^Su14 is a suppressor of eye phenotype of asp¹

(Inoue and Glover, 1998)

rl^Su14 is a suppressor of wing phenotype of asp¹

(Inoue and Glover, 1998)

rl^Su14 is a suppressor of eye phenotype of asp^DD3

(Inoue and Glover, 1998)

rl^Su14 is a suppressor of wing phenotype of asp^DD3

(Inoue and Glover, 1998)

rl^Su14 is a suppressor of phenotype of aos^hs.PSa

(Sawamoto et al., 1996)

NOT Suppressor of

Statement

Reference

rl^Su14 is a non-suppressor of embryo | posterior phenotype of fs(1)M3¹⁹⁰¹

(Lim et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Fully suppresses the phl¹ phenotype in terms of viability and the morphologies of the eye and wing veins. The posterior defects of embryos derived from homozygous fs(1)M3¹⁹⁰¹ females are not suppressed if the females are also carrying one or two copies of rl^Su14. Enhances the tor^11D phenotype; considerable numbers of embryos laid by females heterozygous for rl^Su14 and tor^11D fail to hatch at 28^oC.

(Lim et al., 1999)

Suppresses the morphological defects and sterility of asp¹/asp^DD3 mutants.

(Inoue and Glover, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

rl^Su14

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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