FlyBase Allele Report: Dmel\fs(1)M3[1901]

General Information

Symbol

Dmel\fs(1)M3¹⁹⁰¹

Species

D. melanogaster

Name

FlyBase ID

FBal0004380

Feature type

allele

Associated gene

Dmel\fs(1)M3

Associated Insertion(s)

Carried in Construct

Also Known As

fs(1)ph¹⁹⁰¹

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Pignoni et al., 1992)

Mutagen

ethyl methanesulfonate

(Degelmann et al., 1990)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y742N.

(Jimenez et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:5,961,512..5,961,512 [-]

Nucleotide change:

T5961512A

Amino acid change:

Y783N | fs(1)M3-PA

Reported amino acid change:

Y742N

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Position differs slightly from author statement.

(Jimenez et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | maternal effect

(Degelmann et al., 1990, Mohler and Carroll, 1984)

Phenotype Manifest In

abdominal segment 5

(Ambrosio et al., 1989)

abdominal segment 6

(Ambrosio et al., 1989)

abdominal segment 7

(Ambrosio et al., 1989)

abdominal segment 8

(Ambrosio et al., 1989)

abdominal segment 8 | maternal effect

(Degelmann et al., 1990)

abdominal segment 9

(Ambrosio et al., 1989)

abdominal segment 10

(Ambrosio et al., 1989)

cephalic furrow

(Ambrosio et al., 1989)

cephalopharyngeal skeleton

(Lim et al., 1999)

cephalopharyngeal skeleton | maternal effect

(Stevens et al., 2003, Degelmann et al., 1990)

embryo | anterior

(Lim et al., 1999)

embryo | posterior

(Lim et al., 1999)

embryonic abdominal segment 8

(Lim et al., 1999)

head | anterior | maternal effect

(Degelmann et al., 1990)

labrum

(Ambrosio et al., 1989)

ocular segment

(Ambrosio et al., 1989)

telson

(Ambrosio et al., 1989)

telson | maternal effect

(Degelmann et al., 1990)

terminalia | maternal effect

(Stevens et al., 2003)

ventral furrow

(Ambrosio et al., 1989)

Detailed Description

Statement

Reference

Homozygous mutant mothers produce embryos with a terminal loss-of-function phenotype. The embryo lacks all structures posterior to abdominal segment 8 and the head skeleton is reduced in size.

(Stevens et al., 2003)

Embryos derived from homozygous females fail to develop structures posterior to the seventh abdominal segment as well as anterior-most structures, including the head skeleton.

(Lim et al., 1999)

Embryos derived from homozygous females show a terminal phenotype.

(Furriols et al., 1998)

Posterior defect is significantly suppressed, in a dose-dependent manner, by Dsor1^Su1.

(Tsuda et al., 1993)

Collapsed egg phenotype. Little or no tll expression is detected in the posterior of syncytial or cellular blastoderm embryos, at the anterior the early tll cap does not appear and an abnormal anterior tll stripe appears by the late syncytial blastoderm.

(Pignoni et al., 1992)

Failure to differentiate cuticular structures derived from the anterior and posterior regions of the egg. Double homozygous females fs(1)N¹², fs(1)M3¹⁹⁰¹ produce embryos with the terminal cuticle phenotype.

(Degelmann et al., 1990)

A hole is seen in the blastoderm layer below the pole cells in embryos. The ventral furrow is extended posteriorly. Segments A8 to the telson are deleted. Segments A5 to A7 are expanded. Some twisting of the germband is seen. Labral and acron-derived structures are deleted. There is cell death in the head and tail region. Cephalic furrow and anterior midgut invagination are shifted anteriorly.

(Ambrosio et al., 1989)

Terminal holes in embryo. Embryonic defects detectable at preblastoderm stages. Eggs are laid and some collapse on deposition.

(Mohler and Carroll, 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryo | posterior phenotype, enhanceable by rl[+]/rl⁹

(Lim et al., 1999)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryonic abdominal segment 8 phenotype, enhanceable by rl[+]/rl⁹

(Lim et al., 1999)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryo | posterior phenotype, enhanceable by rl[+]/rl^10a

(Lim et al., 1999)

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryonic abdominal segment 8 phenotype, enhanceable by rl[+]/rl^10a

(Lim et al., 1999)

NOT Enhanced by

Statement

Reference

fs(1)M3¹⁹⁰¹ has cephalopharyngeal skeleton | maternal effect phenotype, non-enhanceable by Scer\GAL4^ET3/tsl^UAS.cSa

(Stevens et al., 2003)

fs(1)M3¹⁹⁰¹ has terminalia | maternal effect phenotype, non-enhanceable by Scer\GAL4^ET3/tsl^UAS.cSa

(Stevens et al., 2003)

Suppressed by

Statement

Reference

fs(1)M3¹⁹⁰¹ has embryo | posterior phenotype, suppressible by Dsor1^Su1

(Lim et al., 1999)

NOT suppressed by

Statement

Reference

fs(1)M3¹⁹⁰¹ has terminalia | maternal effect phenotype, non-suppressible by Scer\GAL4^ET3/tsl^UAS.cSa

(Stevens et al., 2003)

fs(1)M3¹⁹⁰¹ has cephalopharyngeal skeleton | maternal effect phenotype, non-suppressible by Scer\GAL4^ET3/tsl^UAS.cSa

(Stevens et al., 2003)

fs(1)M3¹⁹⁰¹ has embryo | posterior phenotype, non-suppressible by rl^Su14

(Lim et al., 1999)

fs(1)M3¹⁹⁰¹ has embryo | posterior phenotype, non-suppressible by rl^Su23

(Lim et al., 1999)

Suppressor of

Statement

Reference

fs(1)M3¹⁹⁰¹ is a suppressor of embryonic segment phenotype of tsl^tor.PF

(Furriols et al., 1998)

Other

Statement

Reference

Dsor1^Su1, fs(1)M3¹⁹⁰¹ has embryonic abdominal segment 8 phenotype

(Lim et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of tsl^Scer\UAS.cSa driven by Scer\GAL4^ET3 has no effect on the terminal phenotype seen in embryos laid by fs(1)M3¹⁹⁰¹ mothers.

(Stevens et al., 2003)

The fs(1)M3¹⁹⁰¹ posterior embryo defect is significantly suppressed if the female is also carrying one copy of Dsor1^Su1; an eighth abdominal segment is formed. This suppression is significantly reduced if the females are also carrying one copy of rl⁹, rl^10a or Df(2R)rl10b. The posterior defects of embryos derived from homozygous fs(1)M3¹⁹⁰¹ females are not suppressed if the females are also carrying one copy of rl^Su23 or one or two copies of rl^Su14.

(Lim et al., 1999)

Embryos derived from fs(1)M3¹⁹⁰¹ females carrying tsl^tor.PF show no rescue of the fs(1)M3¹⁹⁰¹ phenotype and do not show deletions of the middle segments ("splice" phenotype seen in wild-type embryos carrying tsl^tor.PF).

(Furriols et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4328

fs(1)M3¹⁹⁰¹/FM7a

Kyoto

107691

fs(1)M3¹⁹⁰¹/FM7a

Notes on Origin

Discoverer

Comments

A strong allele of fs(1)M3.

(Pignoni et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

fs(1)1901

(Degelmann et al., 1990)

fs(1)E1901

fs(1)M3¹⁹⁰¹

fs(1)M3⁶

fs(1)ph¹⁹⁰¹

(Stevens et al., 2003, Jimenez et al., 2002, Casali and Casanova, 2001, Cernilogar et al., 2001, Lim et al., 1999, Furriols et al., 1998, Sprenger and Nusslein-Volhard, 1993, Tsuda et al., 1993, Degelmann et al., 1990, Grau and Gutzeit, 1990)

fs(1)ph^E1901

(Gao et al., 1996)

fs(1)pole hole¹⁹⁰¹

(Ambrosio et al., 1989)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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