FlyBase Allele Report: Dmel\ss[D115.7]

General Information

Symbol

Dmel\ss^D115.7

Species

D. melanogaster

Name

FlyBase ID

FBal0090112

Feature type

allele

Associated gene

Dmel\ss

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Kozu et al., 2006, Duncan et al., 1998)

Mutagen

X ray

(Duncan et al., 1998)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Duncan et al., 1998)

Description

Intragenic deletion, within the ss transcription unit. Proximal break between coordinates +21 and +23; distal break between coordinates +13 and +14kb.

(Duncan et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:16,379,122..16,388,935 [-]

Linked to:

BamHI-EcoRI restriction fragment

Comment:

Approximate boundaries of an intragenic deletion with the distal break between +13 and +14 and the proximal break between +21 and +23 in the coordinate system of FBrf0102306. The deletion roughly maps to a BamHI-EcoRI fragment on the Figure 1 map.

(Duncan et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Kim et al., 2006)

abnormal neuroanatomy (with ss¹³⁴)

(Kim et al., 2006)

abnormal neuroanatomy | somatic clone

(Kim et al., 2006)

visible (with Df(3R)ss-D114.4)

(Emmons et al., 2007, Emerald and Cohen, 2004)

visible (with ss^D114.9)

(Kozu et al., 2006)

visible | homeotic

(Duncan et al., 1998)

visible | recessive

(Emmons et al., 1999)

Phenotype Manifest In

antenna

(Emmons et al., 1999, Duncan et al., 1998)

antennal sense organ

(Duncan et al., 1998)

arista (with Df(3R)ss-D114.4)

(Emmons et al., 2007)

dendrite & dorsal multidendritic neuron ddaB | somatic clone

(Kim et al., 2006)

dendrite & dorsal multidendritic neuron ddaC | somatic clone

(Kim et al., 2006)

dendrite & dorsal multidendritic neuron ddaD | somatic clone

(Kim et al., 2006)

dendrite & dorsal multidendritic neuron ddaE

(Kim et al., 2006)

dendrite & dorsal multidendritic neuron ddaE (with ss¹³⁴)

(Kim et al., 2006)

dendrite & dorsal multidendritic neuron ddaE | somatic clone

(Kim et al., 2006)

dendrite & dorsal multidendritic neuron ddaF | somatic clone

(Kim et al., 2006)

dendrite & lateral multidendritic neuron ldaB | somatic clone

(Kim et al., 2006)

dorsomedial papilla

(Duncan et al., 1998)

leg

(Emmons et al., 1999)

leg disc (with ss^D114.9)

(Kozu et al., 2006)

macrochaeta

(Emmons et al., 1999, Duncan et al., 1998)

maxillary palp

(Emmons et al., 1999)

metatarsus

(Duncan et al., 1998)

pale ommatidium | ectopic

(Wernet et al., 2006)

pale ommatidium | ectopic | somatic clone

(Wernet et al., 2006)

photoreceptor cell R7 of pale ommatidium | ectopic | somatic clone

(Wernet et al., 2006)

photoreceptor cell R7 of yellow ommatidium | somatic clone

(Wernet et al., 2006)

pretarsus (with ss^D114.9)

(Kozu et al., 2006)

pretarsus | ectopic (with Df(3R)ss-D114.4)

(Emmons et al., 2007)

tarsal segment

(Emmons et al., 1999, Duncan et al., 1998)

tarsal segment 2

(Duncan et al., 1998)

tarsal segment 2 (with ss^D114.9)

(Kozu et al., 2006)

tarsal segment 3

(Duncan et al., 1998)

tarsal segment 3 (with ss^D114.9)

(Kozu et al., 2006)

tarsal segment 4

(Duncan et al., 1998)

tarsal segment 4 (with ss^D114.9)

(Kozu et al., 2006)

tarsal segment (with Df(3R)ss-D114.4)

(Emerald and Cohen, 2004)

third segment of antenna (with Df(3R)ss-D114.4)

(Emmons et al., 2007)

unguis | ectopic (with Df(3R)ss-D114.4)

(Emmons et al., 2007)

yellow ommatidium

(Wernet et al., 2006)

yellow ommatidium | somatic clone

(Wernet et al., 2006)

Detailed Description

Statement

Reference

Antennal segments 1 and 2 are basically normal in ss^D115.7/Df(3R)ss-D114.4 animals apart from a reduction in bristle size. Antennal segment 3 is composed of naked cuticle and the arista is turned into a fifth tarsal segment with claws.

(Emmons et al., 2007)

Third larval instar ss^D115.7 and ss¹³⁴/ss^D115.7 mutants show defects in class I dendrite morphogenesis; primary branch overgrowth and increased terminal branching of the class I dendrites is seen.

Single cell ss^D115.7 clones (generated using the MARCM technique) of the ddaE neuron show increased terminal branching, while the outgrowth of primary dendrites is mostly unaffected.

Single cell ss^D115.7 clones (generated using the MARCM technique) of the ddaD neuron show increased branching and dendrite routing defects. Secondary dendrites are misoriented and branches improperly terminate posterior to the cell body.

Single cell ss^D115.7 clones (generated using the MARCM technique) of the ddaB neuron show increased dendritic branching at the distal tips of primary and secondary dendrites.

Single cell ss^D115.7 clones (generated using the MARCM technique) of the ddaC neuron show reduced terminal branching and failure of dendrites to reach the dorsal midline. In contrast to the dendrite defects, the axon projections of these mutant clones show no obvious abnormality.

Single cell ss^D115.7 clones (generated using the MARCM technique) of the ldaB neuron show a reduction of dendritic spikes along all major branches. In contrast to the dendrite defects, the axon projections of these mutant clones show no obvious abnormality.

Single cell ss^D115.7 clones (generated using the MARCM technique) of the ddaF neuron show a reduction in the number of dendritic spikes and show clusters of longer terminal branches along the primary dendrites. In contrast to the dendrite defects, the axon projections of these mutant clones show no obvious abnormality.

The td neuron does not show any dendrite defects in ss^D115.7 mutants.

(Kim et al., 2006)

In ss^D114.9/ss^D115.7 mutant legs, the tarsal segments ta2, ta3, and ta4 appear to be missing while the distal-most tarsal segment is present but malformed. Small, ectopic protrusions can occasionally be observed in ta1 of these mutants. At the leg disc stage, cells that normally develop into tarsal segments ta3-ta5 may possibly acquire the ta5 fate at a very early third instar stage and also incorporate the ta4 fate at subsequent stages to form a ta5/ta4 hybrid tarsus in late third instar.

(Kozu et al., 2006)

When somatic clones of ss^D115.7 are induced throughout the eye disc using Scer\FLP1^ey.PN, eyes appear morphologically normal, but marker analysis indicates transformation of almost all yellow ommatidia into pale ommatidia.

In eyes in which R1, R6 and R7 are made homozygous for ss^D115.7 by inducing somatic recombination using Scer\FLP1^GMR.PP, marker analysis indicates that all R7 cells adopt a pale ommatidium R7 cell fate.

ss^D115.7 heterozygous flies show a small but significant reduction in the ratio of yellow to pale ommatidia.

(Wernet et al., 2006)

ss^D115.7/Df(3R)ss-D114.4 animals show fusion of tarsal segments in the leg.

(Emerald and Cohen, 2004)

ss^D114.7/ss^D115.7 flies show transformation of the antenna to tarsus. Homozygotes show transformation of the antenna to a tarsus which does not show segmentation. Deletions of tarsal segments are seen in the leg. Distal deletions are seen in the maxillary palps. Homozygous clones result in a severe reduction in bristle size.

(Emmons et al., 1999)

Null phenotype. Antennal transformations, reduction in bristle size and tarsal deletions. A3 has no bristles or trichomes and most of the distal tarsal region is absent. Tarsal segments 2-4 and part of segment 1 are deleted. First antennal sense organ is cauliflower shaped and has no clear stalk and the migration of the dorsomedial papilla is impaired.

(Duncan et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

ss^D115.7 is a suppressor of third segment of antenna | ectopic | somatic clone phenotype of Antp^Ns-rvC3

(Emerald and Cohen, 2004)

NOT Suppressor of

Statement

Reference

ss^D115.7 is a non-suppressor of photoreceptor cell R8 of yellow ommatidium | ectopic phenotype of sev^unspecified

(Wernet et al., 2006)

ss^D115.7 is a non-suppressor of photoreceptor cell R7 of pale ommatidium phenotype of sev^unspecified

(Wernet et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Transformation of pale ommatidium type R8 cells into yellow ommatidium type R8 cells in sev^unspecified homozygous is unaffected if the eyes are also ss^D115.7/ss^D115.7.

(Wernet et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ss^D115.7/ss¹³⁴ is rescued by ss^UAS.A5/Scer\GAL4²²¹

(Kim et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

78357

w^*; ss^D115.7/TM3, P{HB-lacZ}GS2, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

SsDel115.7

(Ainsworth et al., 2025)

ss^115.7

(Emerald and Cohen, 2004)

ss^D115-7

(Joulia et al., 2006)

ss^D115.7

(Urban et al., 2023, Voortman et al., 2022, Natori et al., 2012, Long et al., 2009, Emmons et al., 2007, Kim et al., 2006, Kozu et al., 2006)

ss^d115.7

(Viets et al., 2019, Yan et al., 2017, Johnston and Desplan, 2014, Thanawala et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

Open Close