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Citation
Hombría, J.C., Sotillos, S. (2013). JAK-STAT pathway in Drosophila morphogenesis: From organ selector to cell behavior regulator.  JAKSTAT 2(3): e26089.
FlyBase ID
FBrf0222814
Publication Type
Review
Abstract

One of the main contributions of Drosophila to the JAK-STAT field is the study of morphogenesis. JAK-STAT signaling controls the formation of many different structures through surprisingly different morphogenetic behaviors that include induction of cell rearrangements, invagination, folding of tissues, modulation of cell shape, and migration. This variability may be explained by the many transcription factors and signaling molecules STAT regulates at early stages of development. But is STAT just acting as an upstream inducer of morphogenesis or does it have a more direct role in controlling cell behaviors? Here we review what is known about how the canonical phosphorylation of STAT contributes to shaping the embryonic and imaginal structures.

PubMed ID
PubMed Central ID
PMC3772120 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    JAKSTAT
    Title
    JAK-STAT
    ISBN/ISSN
    2162-3988 2162-3996
    Data From Reference