FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Socs36EPZ1647
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General Information
Symbol
Dmel\Socs36EPZ1647
Species
D. melanogaster
Name
FlyBase ID
FBal0243535
Feature type
allele
Associated gene
Dmel\Socs36E
Associated Insertion(s)
P{PZ}Socs36EPZ1647
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Monahan and Starz-Gaiano, 2013)

loss of function allele

(Issigonis et al., 2009)
Mutagen
P-element activity
(Issigonis et al., 2009)
Progenitor genotype
Associated Insertion(s)
P{PZ}Socs36EPZ1647
Cytology
Description

Insertion in the Socs36E coding region.

(Issigonis et al., 2009)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The stem cell niche in homozygous Socs36EPZ1647 or hemizygous Socs36EPZ1647/Df(2L)M36F-S5 mutant testes from newly eclosed males is abnormal. It contains only three to four germ line stem cells as compared with the wild-type average of ten. The typical positions of the missing male germline stem cells are occupied by somatic cells. Cyst progenitor cells form aberrantly broad contacts with the stem cell hub in Socs36EPZ1647 mutant testes.

      Clones of Socs36EPZ1647 mutant male germline stem cells (GSCs) are normal, indicating that the GSCs do not directly require wild-type Socs36E function for their maintenance.

      Clones of Socs36EPZ1647 mutant cyst progenitor cells (CPCs) in the testes out-compete wild-type CPCs. The advantage for niche occupancy that Socs36EPZ1647 mutant CPCs display over their wild-type counterparts even extends to GSCs. The number of mutant CPCs increases, there is a corresponding decline in the number of GSCs.

      (Issigonis et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Socs36EPZ1647 has male germline stem cell phenotype, suppressible by rhea[+]/rhea6-66

      (Issigonis et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for rhea6-66 suppresses the abnormal male germline stem cell number phenotype.

      (Issigonis et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Socs36EPZ1647
      (Gunawan et al., 2013, Monahan and Starz-Gaiano, 2013)
      socs36EPZ1647
      (Issigonis et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)