FB2026_02 , released June 18, 2026
Allele: Dmel\CrkE
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General Information
Symbol
Dmel\CrkE
Species
D. melanogaster
Name
FlyBase ID
FBal0405961
Feature type
allele
Associated gene
Dmel\Crk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Fourth Chromosome Resource Project and Newfeld, 2022-)
Progenitor genotype
Cytology
Description

Frameshift deletion of bases 4:211918 and 4:211919 resulting in the addition of LVDCA after aspartic acid 141 of the Crk RA, RC, RD and RG isoforms and premature truncation after these novel amino acids.

(Fourth Chromosome Resource Project and Newfeld, 2022-)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
4:211,918..211,919 [+]
Comment:

Deletion of bases 4:211918..211919 in Crk results in a frameshift and early translation termination after the additon of 5 novel amino acids (LVDCA) in the Crk RA, RB, RC, RD and RE isoforms.

(Fourth Chromosome Resource Project and Newfeld, 2022-)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CrkE
      (Weasner et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)