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FB2026_01
,
released March 12, 2026
βH, βH-spectrin, βHeavy-spectrin, βH-Spectrin, βH spectrin
cytoskeletal protein - structural and docking protein - a junctional protein involved in cell adhesion - Spectrin regulates Hippo signaling by modulating cortical actomyosin activity
Please see the JBrowse view of Dmel\kst for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
13.0 | predicted (northern blot)
430 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kst using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Immunolocalization was performed in a GMR > alpha- catenin::GFP background to provide a cytoskeletal marker, as phalloidin staining was incompatible with the fixation protocol used. Expression is reduced in 44-46 hours APF timepoint compared to earlier timepoints.
JBrowse - Visual display of RNA-Seq signals
View Dmel\kst in JBrowse
3-8
3-6.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells.
kst is essential for normal epithelium morphogenesis of the follicle cell epithelium during oogenesis.
kst mutant individuals have a pleiotropic phenotype characterised by extensive larval lethality and, in adult escapers, rough eyes, bent wings, tracheal defects and infertility.
The kst gene product is a component of neither fusomes nor spectrosomes.
The locus has been named "karst" as scanning electron micrographs of kst mutant eyes resemble the morphology of certain karst landforms.
