FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\jbug
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General Information
Symbol
Dmel\jbug
Species
D. melanogaster
Name
jitterbug
Annotation Symbol
CG30092
Feature Type
protein_coding_gene
FlyBase ID
FBgn0289650
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
jitterbug (jbug) encodes a Filamin-type protein. Filamins are actin crosslinkers that organize actin filaments into networks and connect them to membrane receptors. The product of jbug is required in photoreceptor cells for axon targeting and in notum tendon cells to maintain its shape during muscle-tendon interaction. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

moa, Filamin

Key Links
Genomic Location
Cytogenetic map
59A3-59A3
Sequence location
Recombination map
2-101
RefSeq locus
NT_033778 REGION:22717321..22740459
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables actin filament binding
inferred from electronic annotation with InterPro:IPR044801
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in establishment of body hair or bristle planar orientation
inferred from mutant phenotype
(Olguín et al., 2011)
involved_in photoreceptor cell axon guidance
inferred from mutant phenotype
(Oliva et al., 2015)
involved_in response to mechanical stimulus
inferred from genetic interaction with FLYBASE:kcc; FB:FBgn0261794
(Hekmat-Scafe et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from electronic annotation with InterPro:IPR044801
(InterPro Project Members, 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
jitterbug (jbug) encodes a Filamin-type protein. Filamins are actin crosslinkers that organize actin filaments into networks and connect them to membrane receptors. The product of jbug is required in photoreceptor cells for axon targeting and in notum tendon cells to maintain its shape during muscle-tendon interaction. [Date last reviewed: 2018-10-11]
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\jbug for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KFF9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
jbug-RC
FBtr0071919
NM_166550
1898
410
jbug-RF
FBtr0301374
NM_166546
9430
2955
jbug-RG
FBtr0301375
NM_001169785
1939
410
jbug-RH
FBtr0301376
NM_001169786
1845
410
jbug-RI
FBtr0301377
NM_001169787
5989
1752
jbug-RJ
FBtr0302116
NM_001169788
2146
410
jbug-RK
FBtr0302117
NM_001169789
1908
410
jbug-RL
FBtr0302374
NM_166547
5339
1613
jbug-RM
FBtr0330233
NM_001274210
9043
2839
jbug-RN
FBtr0330234
NM_001274211
9391
2990
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
jbug-PC
FBpp0071830
42.4
410
6.12
Q8MME5
NP_726238
AAM71119
jbug-PF
FBpp0290588
318.9
2955
7.32
Q9W205
NP_726234
AAF46895
jbug-PG
FBpp0290589
42.4
410
6.12
Q8MME5
NP_001163256
ACZ94528
jbug-PH
FBpp0290590
42.4
410
6.12
Q8MME5
NP_001163257
ACZ94529
jbug-PI
FBpp0290591
185.7
1752
6.51
E1JGS7
NP_001163258
ACZ94530
jbug-PJ
FBpp0291326
42.4
410
6.12
Q8MME5
NP_001163259
ACZ94531
jbug-PK
FBpp0291327
42.4
410
6.12
Q8MME5
NP_001163260
ACZ94532
jbug-PL
FBpp0291569
175.6
1613
8.12
Q9W204
NP_726235
AAF46896
jbug-PM
FBpp0303266
306.1
2839
7.22
A0A0B4KEX6
NP_001261139
AGB93670
jbug-PN
FBpp0303267
322.7
2990
7.45
A0A0B4KFF9
NP_001261140
AGB93671
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

410 aa isoforms: jbug-PC, jbug-PG, jbug-PH, jbug-PJ, jbug-PK
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jbug using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.80

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
(Arbeitman et al., 2004)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 10 -- 11
embryonic/larval tracheal section
(Chung et al., 2011)
embryonic stage 11 -- 12
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
salivary gland body primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
larval foregut atrium
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
labral segment
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\jbug in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of jbug
Transgenic constructs containing regulatory region of jbug
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2R)59AB)
lethal (with Df(2R)Exel6079)
lethal | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of larval stage | recessive
partially lethal - majority die
partially lethal - majority die (with Df(2R)59AB)
partially lethal - majority die (with jbug20)
partially lethal - majority die (with jbug30)
partially lethal - majority die (with jbug133)
partially lethal - majority die | maternal effect, with Scer\GAL4VP16.mat.αTub67C
partially lethal - majority die | recessive
partially lethal - majority live (with Df(2R)Exel6079)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR.PU
abnormal planar polarity, with Scer\GAL4pnr-MD237
bang sensitive
decreased size | adult stage
decreased size | adult stage, with Scer\GAL469B
decreased size | adult stage, with Scer\GAL4da.G32
decreased size | adult stage (with Df(2R)59AB)
decreased size | adult stage (with jbug20)
decreased size | adult stage (with jbug30)
decreased size | adult stage (with jbug133)
some die during larval stage | recessive
some die during pupal stage
visible | somatic clone
Phenotype manifest in
Allele
adult thorax
adult thorax, with Scer\GAL469B
adult thorax, with Scer\GAL4da.G32
adult thorax (with Df(2R)59AB)
adult thorax (with jbug20)
adult thorax (with jbug30)
adult thorax (with jbug133)
axon | adult stage, with Scer\GAL4GMR.PU
denticle | decreased number | embryonic stage 16
denticle | decreased number | embryonic stage 16, with Scer\GAL4da.G32
denticle | decreased number | embryonic stage 16 | maternal effect, with Scer\GAL4VP16.mat.αTub67C
denticle | embryonic stage 16
denticle | embryonic stage 16, with Scer\GAL4da.G32
denticle | embryonic stage 16 | increased number, with Scer\GAL4da.G32
embryo | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, Scer\GAL4da.G32
embryonic/larval salivary gland | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, Scer\GAL4da.G32
embryonic epidermis | embryonic stage 16, with Scer\GAL4da.G32
eye photoreceptor cell | adult stage, with Scer\GAL4GMR.PU
larva
macrochaeta
macrochaeta, with Scer\GAL469B
macrochaeta, with Scer\GAL4da.G32
macrochaeta (with Df(2R)59AB)
macrochaeta (with jbug20)
macrochaeta (with jbug30)
macrochaeta (with jbug133)
macrochaeta | pupal stage
macrochaeta | pupal stage, with Scer\GAL4da.G32
wing | somatic clone
wing hair
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (28)
Hsap\FLNA
4 of 14
Yes
No
Hsap\FLNB
4 of 14
Yes
No
1  
Hsap\FLNC
4 of 14
Yes
No
Hsap\ACTN1
1 of 14
No
No
Hsap\ACTN2
1 of 14
No
No
Hsap\ACTN3
1 of 14
No
No
Hsap\ACTN4
1 of 14
No
No
5  
Hsap\CLMN
1 of 14
No
No
Hsap\DIXDC1
1 of 14
No
Yes
Hsap\DMD
1 of 14
No
No
Hsap\DST
1 of 14
No
No
Hsap\GAS2L2
1 of 14
No
No
Hsap\LCP1
1 of 14
No
No
1  
Hsap\MACF1
1 of 14
No
No
Hsap\PLEC
1 of 14
No
No
Hsap\PLS1
1 of 14
No
No
Hsap\PLS3
1 of 14
No
No
1  
Hsap\SPTB
1 of 14
No
No
1  
Hsap\SPTBN1
1 of 14
No
No
Hsap\SPTBN2
1 of 14
No
No
3  
Hsap\SPTBN4
1 of 14
No
No
Hsap\SPTBN5
1 of 14
No
No
Hsap\SYNE1
1 of 14
No
No
Hsap\SYNE2
1 of 14
No
No
Hsap\TRIM2
1 of 14
No
No
Hsap\TRIM3
1 of 14
No
No
Hsap\TRIM71
1 of 14
No
No
Hsap\UTRN
1 of 14
No
No
7  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Flnb
4 of 14
Yes
No
Rnor\Flnc
4 of 14
Yes
No
Rnor\Flna
3 of 14
No
No
Rnor\Gas2l2
1 of 14
No
No
Mus musculus (laboratory mouse) (4)
Mmus\Flna
4 of 14
Yes
No
Mmus\Flnb
4 of 14
Yes
No
Mmus\Flnc
3 of 14
No
No
Mmus\Gas2l2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\flnc
2 of 13
Yes
No
Xtro\actn1
1 of 13
No
No
Xtro\dmd.3
1 of 13
No
No
Xtro\flna
1 of 13
No
No
Xtro\flnb
1 of 13
No
No
Xtro\sptbn2
1 of 13
No
No
Xtro\sptbn4
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\flnb
4 of 14
Yes
No
Drer\flnca
4 of 14
Yes
No
Drer\flncb
4 of 14
Yes
No
Drer\flna
3 of 14
No
No
Drer\flnb
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\fln-2
11 of 14
Yes
Yes
Cele\fln-1
3 of 14
No
No
Cele\anc-1
1 of 14
No
No
Cele\atn-1
1 of 14
No
No
Cele\M116.5
1 of 14
No
No
Cele\plst-1
1 of 14
No
No
Cele\sma-1
1 of 14
No
No
Cele\unc-70
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP007006
11 of 12
Yes
Yes
Agam\AgaP_AGAP004335
2 of 12
No
No
Agam\ACTN_ANOGA
1 of 12
No
No
Agam\AgaP_AGAP004071
1 of 12
No
No
Agam\AgaP_AGAP004440
1 of 12
No
No
Agam\AgaP_AGAP010895
1 of 12
No
No
Agam\AgaP_AGAP011397
1 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (6)
Atha\AT4G21820
1 of 13
Yes
No
Atha\AT5G48460
1 of 13
Yes
No
Atha\AT5G55400
1 of 13
Yes
No
Atha\FIM1
1 of 13
Yes
No
Atha\FIM5
1 of 13
Yes
No
Atha\GEX2
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SAC6
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:jbug. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (10)
cher
4 of 13
Actn
2 of 13
β-Spec
2 of 13
CG5984
2 of 13
Dys
2 of 13
kst
2 of 13
α-Spec
1 of 13
Dyb
1 of 13
Fim
1 of 13
shot
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 16 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FLNA; filamin A
    4 of 14
    300017
    FLNB; filamin B
    4 of 14
    603381
     
    FLNC; filamin C
    4 of 14
    102565
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    jbug
    enhanceable
    chas
    (Olguín et al., 2011)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    chas
    enhanceable
    jbug
    (Olguín et al., 2011, Olguín et al., 2011)
    chas
    suppressible
    jbug
    (Olguín et al., 2011)
    if
    enhanceable
    jbug
    (Walsh and Brown, 1998)
    kcc
    enhanceable
    jbug
    (Hekmat-Scafe et al., 2006)
    mew
    enhanceable
    jbug
    (Walsh and Brown, 1998)
    mys
    enhanceable
    jbug
    (Walsh and Brown, 1998)
    peb
    suppressible
    jbug
    (Oliva et al., 2015)
    External Data
    Linkouts
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-101
    Cytogenetic map
    59A3-59A3
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    59A3-59A3
    Limits computationally determined from genome sequence between P{EP}ppaEP698&P{EP}EP2184 and P{PZ}blw03972
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    The moa complementation group maps to the genomic interval 2R:22729367..22764935 , release 6 genome (left limit from complementation mapping against Df(2R)Exel6079, right limit from complementation mapping against Df(2R)BSC865).
    (Kahsai and Cook, 2018)
    59A-59A
    (Brown et al., 2000, Ren, 1999.9.17)
    Experimentally Determined Recombination Data
    Location

    2-101

    (FlyBase, 2016)

    2-105.7

    (Comeron et al., 2012)

    2-

    (Prout et al., 1997)
    Left of (cM)
    Right of (cM)
    Notes

    Located on 2R.

    (Prout et al., 1997)
    Stocks and Reagents
    Stocks (20)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (95)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Chung et al., 2021)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and ClkJrk background.

          (Claridge-Chang et al., 2001)

          Identification: Genetic screen for mutations that produce blisters in somatic wing clones. 2 "sac" alleles have been isolated.

          (Walsh and Brown, 1998)

          Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones.

          (Prout et al., 1997)

          Mutations may affect cell adhesion or muscle function at hatching.

          (Prout et al., 1997)

          Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones. 4 alleles of moa have been isolated.

          (Prout et al., 1997)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: jbug CG11605 CG13525

          (Ren, 2002.3.8)

          Source for merge of: CG11605 CG3550

          (Misra, 2001.8.10, FlyBase, 1996-)

          Source for merge of: jbug moa

          (Brown, 2023.9.6)
          Additional comments

          The moa complementation group corresponds to one (or more) of the following annotated genes: jbug, CG13526, CR30267.

          (Kahsai and Cook, 2018)

          Annotations CG3550, CG11605, CG13525 merged as CG30092 in release 3 of the genome annotation.

          (FlyBase Genome Annotators, 2002-2003)

          Source for merge of CG11605 CG3550 was a shared cDNA ( date:010720 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of

          Source for identity of: jbug Filamin

          (Ren, 2002.3.8)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (13)
          Reported As
          Symbol Synonym
          AAF46896
          (Korenbaum and Rivero, 2002)
          CG11605
          (Arbeitman et al., 2004, Claridge-Chang et al., 2001, Brown, 2000.7.20)
          CG13525
          (Brown, 2000.7.20)
          CG30092
          (National Institute of Genetics Fly Stocks, 2022-, Sing et al., 2014, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008)
          CG3550
          (Misra, 2001.8.10)
          Jbug
          (Nakamura et al., 2020, Manieu et al., 2018, Gan et al., 2010)
          jbug
          (Mulder et al., 2025, Brown, 2023.9.6, Chung et al., 2021, DeAngelis et al., 2021, Fortuna et al., 2021, Hope et al., 2020, Transgenic RNAi Project members, 2017-, Loganathan et al., 2016, Kroll et al., 2015, Oliva et al., 2015, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Chung et al., 2011, Jungreis et al., 2011, Olguín et al., 2011, Olguín et al., 2011, Nedelsky et al., 2010, Bakal et al., 2007, Hekmat-Scafe et al., 2006, Liebl et al., 2006, Song and Tanouye, 2006)
          l(2)59ABd
          (Jacobs et al., 1998)
          moa
          (Brown, 2023.9.6, Kahsai and Cook, 2018, Carmon et al., 2010, MacIntyre et al., 2007)
          sac
          (Walsh and Brown, 1998)
          Name Synonyms
          Filamin
          (Ren, 2002.3.8, Silverman and Maniatis, 2001, van der Flier and Sonnenberg, 2001, Brown, 2000.7.20, Brown et al., 2000)
          filamin
          (Landis et al., 2003, Miller, 2002, Petit et al., 2002)
          jitterbug
          (Kroll et al., 2015, Olguín et al., 2011, Bakal et al., 2007, Hekmat-Scafe et al., 2006, Song and Tanouye, 2006, Harbison et al., 2005, Ren, 1999.9.17)
          moa
          (Carmon et al., 2010, Prout et al., 1997)
          Secondary FlyBase IDs
          • FBgn0028371
          • FBgn0034772
          • FBgn0034773
          • FBgn0040659
          • FBgn0041831
          • FBgn0050092
          • FBgn0020271
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 72 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          References (94)