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General Information
Symbol
Dmel\kst2
Species
D. melanogaster
Name
FlyBase ID
FBal0064834
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Border cells migrate ahead of outer follicle cells in 72% of kst2/kst01318 egg chambers.

Most of the kst2/Df(3L)1226 mutant larvae die as larvae.

Most of the kst2/kstB1-14.1 mutant larvae die as larvae.

Rhabdomeres of kst1/kst2 mutant eyes show defects in rhabdomere shape similar to, but less marked than those of crb mutants. Stalk membranes are 10% shorter than wild type and lack the wild type deep folds.

Mutant embryos hatch, but mutant pupae are present at less than 10% of the expected number, suggesting that most individuals die as larvae. There seems to be little pupal lethality and kst mutants eclose 2-4 days behind their wild-type siblings. Adult escapers are very infertile and lay few eggs. kst1/kst2 adult escapers have rough eyes and wings that typically curve downwards in an "inverted spoon" shape. The R7 photoreceptor cell is missing in many ommatidia in kst2/Df(3L)1226 escapers.

Homozygotes generally die as larvae. Surviving adults have defects in the eyes, wings and tracheal system.

Hemizygotes have irregular or missing facets in a region of variable size at the posterior margin of the eye. The wings show a variable degree of downward curvature and the flies tend to "leak" haemolymph, particularly through the spiracles of the abdomen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

kst1/kst2 has lethal phenotype, enhanceable by crb11A22/crb[+]

kstB1-14.1/kst2 has lethal phenotype, enhanceable by crb11A22/crb[+]

Suppressed by
Statement
Reference

Df(3L)1226/kst2 has lethal | larval stage phenotype, suppressible | partially by Pak[+]/Pak6

kstB1-14.1/kst2 has lethal | larval stage phenotype, suppressible | partially by Pak[+]/Pak6

Enhancer of
Statement
Reference

kst[+]/kst2 is an enhancer of visible phenotype of Scer\GAL4GMR.PFa, trioUAS.cBa

NOT Enhancer of
Statement
Reference

kst[+]/kst2 is a non-enhancer of lethal | embryonic stage | partially | recessive phenotype of peb308

NOT Suppressor of
Statement
Reference

kst[+]/kst2 is a non-suppressor of lethal | embryonic stage | partially | recessive phenotype of peb308

Phenotype Manifest In
Enhanced by
Statement
Reference

kst1/kst2 has rhabdomere | somatic clone phenotype, enhanceable by crb11A22/crb[+]

NOT Enhanced by
Statement
Reference

kst01318/kst2 has follicle cell phenotype, non-enhanceable by sosief00514/CG13636[+]

NOT suppressed by
Statement
Reference

kst01318/kst2 has follicle cell phenotype, non-suppressible by sosief00514/CG13636[+]

Enhancer of
Statement
Reference

kst[+]/kst2 is an enhancer of eye phenotype of Scer\GAL4GMR.PFa, trioUAS.cBa

Other
Additional Comments
Genetic Interactions
Statement
Reference

Border cells migrate ahead of outer follicle cells in 65% of Df(3R)sosie/kst2 double heterozygous egg chambers.

Heterozygosity for kst2 significantly enhances the rough-eye phenotype induced by overexpression of trioScer\UAS.cBa via Scer\GAL4GMR.PFa.

More kst2/Df(3L)1226 mutant larvae that are also heterozygous for Pak6 survive into pupal stages and beyond than kst2/Df(3L)1226 controls.

More kst2/kstB1-14.1 mutant larvae that are also heterozygous for Pak6 survive into pupal stages and beyond than kst2/Df(3L)1226 controls.

Introduction of one copy of kst2 into a homozygous rhove-1 background moderately suppresses the wing vein defect for L2-L4 and partially suppresses the defects in L5.

crb2/crb+, kst1/kst2 mutants have normal zonula adherens but photoreceptor stalk membranes are much shorter than in wild type, kst homozygous or crb heterozygous photoreceptor cells.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0101351
References (13)