FlyBase Allele Report: Dmel\kst[1]

General Information

Symbol

Dmel\kst¹

Species

D. melanogaster

Name

FlyBase ID

FBal0064835

Feature type

allele

Associated gene

Dmel\kst

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Thomas et al., 1998)

Progenitor genotype

Cytology

Description

Encodes a truncated protein.

(Thomas and Kiehart, 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Elongation of rhabdomeres is not affected in kst¹/kst² photoreceptors.

(Richard et al., 2009)

Rhabdomeres of kst¹/kst² mutant eyes show defects in rhabdomere shape similar to, but less marked than those of crb mutants. Stalk membranes are 10% shorter than wild type and lack the wild type deep folds.

(Pellikka et al., 2002)

Mutant embryos hatch, but mutant pupae are present at less than 10% of the expected number, suggesting that most individuals die as larvae. There seems to be little pupal lethality and kst mutants eclose 2-4 days behind their wild-type siblings. Adult escapers are very infertile and lay few eggs. Hemizygous and kst¹/kst² adult escapers have rough eyes. The R7 photoreceptor cell is missing in many ommatidia in kst¹/Df(3L)HR232 escapers. Many ommatidia are missing in the eyes of kst¹/Df(3L)1226 escapers. kst¹/kst² adult escapers have wings that typically curve downwards in an "inverted spoon" shape. Hemizygous adult escapers show a visible extrusion of melanised material from the abdominal spiracles.

(Thomas et al., 1998)

Homozygotes generally die as larvae. Surviving adults have defects in the eyes, wings and tracheal system.

(Thomas and Kiehart, 1995)

Hemizygotes have irregular or missing facets in a region of variable size at the posterior margin of the eye. The wings show a variable degree of downward curvature and the flies tend to "leak" haemolymph, particularly through the spiracles of the abdomen.

(Thomas and Kiehart, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

kst¹/kst² has lethal phenotype, enhanceable by crb^11A22/crb[+]

(Medina et al., 2002)

kst^B1-14.1/kst¹ has lethal phenotype, enhanceable by crb^11A22/crb[+]

(Medina et al., 2002)

Enhancer of

Statement

Reference

kst[+]/kst¹ is an enhancer of visible phenotype of Scer\GAL4^GMR.PFa, trio^UAS.cBa

(Lee and Thomas, 2011)

kst[+]/kst¹ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, crb^{intra.UAS.Tag:MYC}

(Chen et al., 2009)

NOT Enhancer of

Statement

Reference

kst[+]/kst¹ is a non-enhancer of lethal | embryonic stage | recessive | partially phenotype of peb³⁰⁸

(Wilk et al., 2004)

NOT Suppressor of

Statement

Reference

kst[+]/kst¹ is a non-suppressor of lethal | recessive | partially | embryonic stage phenotype of peb³⁰⁸

(Wilk et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

kst¹/kst² has eye photoreceptor cell stalk phenotype, enhanceable by crb^11A22/crb[+]

(Pellikka et al., 2002)

kst¹/kst² has rhabdomere | somatic clone phenotype, enhanceable by crb^11A22/crb[+]

(Pellikka et al., 2002)

Enhancer of

Statement

Reference

kst[+]/kst¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PFa, trio^UAS.cBa

(Lee and Thomas, 2011)

kst[+]/kst¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, crb^{intra.UAS.Tag:MYC}

(Chen et al., 2009)

Suppressor of

Statement

Reference

kst¹ is a suppressor of wing vein L5 phenotype of rho^ve-1

(Tjota et al., 2011)

kst¹ is a suppressor of wing vein L2 phenotype of rho^ve-1

(Tjota et al., 2011)

kst¹ is a suppressor of wing vein L3 phenotype of rho^ve-1

(Tjota et al., 2011)

kst¹ is a suppressor of wing vein L4 phenotype of rho^ve-1

(Tjota et al., 2011)

Other

Statement

Reference

crb^11A22, kst¹/kst² has rhabdomere | somatic clone phenotype

(Pellikka et al., 2002)

crb^11A22, kst¹/kst² has eye photoreceptor cell stalk phenotype

(Pellikka et al., 2002)

crb^11A22/crb[+], kst¹/kst² has rhabdomere | somatic clone phenotype

(Pellikka et al., 2002)

crb^11A22/crb[+], kst¹/kst² has eye photoreceptor cell stalk phenotype

(Pellikka et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for kst¹ significantly enhances the rough-eye phenotype induced by overexpression of trio^Scer\UAS.cBa via Scer\GAL4^GMR.PFa.

(Lee and Thomas, 2011)

Introduction of one copy of kst¹ into a homozygous rho^ve-1 background completely suppresses the wing vein defect for L2-L4 and partially suppresses the defects in L5.

(Tjota et al., 2011)

crb²/crb⁺, kst¹/kst² mutants have normal zonula adherens but photoreceptor stalk membranes are much shorter than in wild type, kst homozygous or crb heterozygous photoreceptor cells.

(Pellikka et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99569

w^*; kst¹/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

karst¹

(Chen et al., 2009)

kst1

(Thomas and Kiehart, 1995)

kst^1-1151

kst¹

(Khanal et al., 2016, Lee and Thomas, 2011, Tjota et al., 2011, Richard et al., 2009)

Name Synonyms

Secondary FlyBase IDs

FBal0101352

References (13)

Report Sections

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