FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\snsRNAi.UAS.WIZ
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General Information
Symbol
Dmel\snsRNAi.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0230426
Feature type
allele
Associated gene
Dmel\sns
Associated Insertion(s)
Carried in Construct
P{UAS-sns.IR.RNAi.WIZ}
Key Links
Transgenic product class
RNAi_reagent
(Zhuang et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Zhuang et al., 2009)
Mutagen
in vitro construct
(Zhuang et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-sns.IR.RNAi.WIZ}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 712bp sns fragment.

(Zhuang et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sns
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  nephrotic syndrome type 1
      CEA
      (Zhuang et al., 2009)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The garland cell nephrocytes of third instar larvae expressing snsdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4sns.GCN have shape defects and are more loosely associated than normal.

      The numbers of nephrocyte diaphragms in the garland cell nephrocytes of second instar larvae expressing snsdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4sns.GCN is reduced compared to controls, although the NDs that do form appear normal by TEM analysis.

      The surface of the garland cell nephrocytes of third instar larvae expressing snsdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4sns.GCN is more uniform than that of control cells when analysed by SEM.

      Garland cell nephrocytes from second instar larvae expressing snsdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4sns.GCN show efficient uptake of dextran 10kD after co-incubation with both Cascade Blue dextran 10kD and fluorescein dextran 500kD for 5 minutes. However, these cells show a very poor uptake of dextran 500kD under these conditions compared to controls.

      (Zhuang et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      snsRNAi.UAS.WIZ
      snsdsRNA.Scer\UAS.WIZ
      snsdsRNA.UAS.WIZ
      Name Synonyms
      Secondary FlyBase IDs
        References (2)