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General Information
Name
CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES
Species
D. melanogaster
Symbol
CAMK
FlyBase ID
FBgg0000240
Date last reviewed
2015-03-25
Number of members
31
Description
Description

The Calcium/Calmodulin-dependent kinase family are serine/threonine kinases which, in general, prefer substrates containing basic residues. Many, but not all, members are regulated by calcium or calmodulin. (Adapted from FBrf0132098).

Notes on Group

trbl is believed to be a pseudokinase and belongs to the tribbles family (PMID:23863185).

Unc-89 is predicted to be a pseudokinase based on sequence analysis in FBrf0209106.

CASK is thought to be a pseudokinase as it lacks the canonical DFG-motif required for Mg2+-binding in its CaM-kinase domain. In the absence of Mg2+ human CASK was shown to autophosphorylate and to phosphorylate bound neurexin-1 at very low catalytic rate (PMID:18423203). Its inhibition by divalent cations suggests that the kinase is inactive in vivo.

Source Material
The CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Sopko et al., 2014, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (31)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
AMP-activated protein kinase α subunit
AMPK, SNF1A, AMP-activated protein kinase, EG:132E8.2, dAMPKα
bent
projectin, twitchin, l(4)23, l(4)2, CT8086
Calcium/calmodulin-dependent protein kinase I
Calcium/calmodulin-dependent protein kinase II
Ca2+/calmodulin-dependent protein kinase II, dCaMKII, CaM kinase II, l(4)16, CaM kinase
CASK
Camguk, Caki, cmg, CASK ortholog, Calcium/calmodulin-dependent protein kinase
Death-associated protein kinase related
grapes
Chk1, lemp, dChk1, 1C, last empress
loki
mnk, Chk2, DmChk2, Checkpoint kinase 2, maternal nuclear kinase
MAP kinase activated protein-kinase-2
MK2, dMK2
par-1
l(2)k06323, MARK, partitioning defective-1, dPAR-1, l(2)27C1
Salt-inducible kinase 2
EG:22E5.8, Salt-induced kinase 2
Stretchin-Mlck
MLCK, myosin light chain kinase, A(225), Stretchin, Mlc-k
Unc-89
obscurin, BEST:HL01080, obs
External Data
Synonyms and Secondary IDs
Synonym(s)
CAMK
CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES
Calcium/Calmodulin-dependent kinases
Calcium/Calmodulin regulated kinases
Ca2+/calmodulin-dependent protein kinase
Calcium-dependent Protein Kinases
CaMK
Secondary FlyBase ID(s)
References (4)