Gene Group: CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

General Information

Name

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

Species

D. melanogaster

Symbol

CAMK

FlyBase ID

FBgg0000240

Date last reviewed

2022-11-01

Number of members

Description

The Calcium/Calmodulin-dependent kinase family are serine/threonine kinases which, in general, prefer substrates containing basic residues. Many, but not all, members are regulated by calcium or calmodulin. (Adapted from FBrf0132098).

Notes on Group

CASK is thought to be a pseudokinase as it lacks the canonical DFG-motif required for Mg[2+]-binding in its CaM-kinase domain. However, in the absence of Mg[2+] human CASK was shown to autophosphorylate and to phosphorylate bound neurexin-1 at very low catalytic rate (PMID:18423203).

trbl is believed to be a pseudokinase belonging to the tribbles family (PMID:23863185) and is therefore omitted from this group.

Unc-89 is predicted to be a pseudokinase based on sequence analysis (FBrf0209106) and is therefore omitted from this group.

Source Material

The CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Manning et al., 2002, and Morrison et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

protein serine/threonine kinase activity

Biological Process

protein phosphorylation

Cellular Component

Enzymatic activity

Enzyme name (EC)

2.7.11.-

Related Gene Groups

Parent group(s)

PROTEIN KINASES