FB2026_03 , released September 17, 2026
CV Term Report
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Term calcium/calmodulin-dependent protein kinase activity ID (Ontology) GO:0004683 (Gene Ontology)
Definition Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. This activity require the presence of calcium-bound calmodulin.[ PubMed:11264466 ]
Also Known As"Ca2+/CaM-dependent kinase activity" ; "calcium- and calmodulin-dependent protein kinase activity" ; "calmodulin regulated protein kinase activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 calcium/calmodulin-dependent protein kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | calcium/calmodulin-dependent protein kinase activity
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  protein kinase activity
   |__protein serine/threonine kinase activity
       |__calcium/calmodulin-dependent protein kinase activity  8 rec.
           |__elongation factor-2 kinase activity
           |__myosin heavy chain kinase activity
           |__phosphorylase kinase activity 1 rec.
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Is a protein serine/threonine kinase activity
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Synonyms
  • "ATP:caldesmon O-phosphotransferase activity" NARROW[ EC:2 ]
    "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" RELATED[ EC:2 ]
    "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW[ EC:2 ]
    "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW[ EC:2 ]
    "Ca2+/calmodulin-dependent protein kinase activity" RELATED[ EC:2 ]
    "Ca2+/calmodulin-dependent protein kinase II activity" NARROW[ EC:2 ]
    "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW[ EC:2 ]
    "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW[ EC:2 ]
    "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW[ EC:2 ]
    "Ca2+/CaM-dependent kinase activity" EXACT
    "calcium- and calmodulin-dependent protein kinase activity" EXACT
    "calcium/calmodulin-dependent protein kinase type II activity" NARROW[ EC:2 ]
    "caldesmon kinase (phosphorylating) activity" NARROW[ EC:2 ]
    "calmodulin regulated protein kinase activity" EXACT
    "calmodulin-dependent kinase II activity" NARROW[ EC:2 ]
    "calmodulin-dependent protein kinase activity" EXACT
    "calmodulin-dependent protein kinase I activity" NARROW
    "CaM kinase activity" RELATED[ EC:2 ]
    "CaM kinase II activity" NARROW[ EC:2 ]
    "CAM PKII" RELATED[ EC:2 ]
    "CaM-regulated serine/threonine kinase activity" RELATED[ EC:2 ]
    "CaMKI" RELATED[ EC:2 ]
    "CaMKII" RELATED[ EC:2 ]
    "CaMKIV" RELATED[ EC:2 ]
    "CaMKKalpha" RELATED[ EC:2 ]
    "CaMKKbeta" RELATED[ EC:2 ]
    "microtubule-associated protein 2 kinase activity" RELATED[ EC:2 ]
    "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED
    "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED
    "STK20" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.11.17
Reactome:R-HSA-111912 "CaMK4 phosphorylates CREB1"
Reactome:R-HSA-111915 "CAMK4 autophosphorylates"
Reactome:R-HSA-416320 "Trafficking of GluR1-containing AMPA receptors"
Reactome:R-HSA-442749 "CaMKK autophosphorylates in the nucleus"
Reactome:R-HSA-9006992 "MECP2 is phosphorylated at S423"
Reactome:R-HSA-9617583 "CaMKII autophosphorylates"
Reactome:R-HSA-9618750 "CaMKII phosphorylates AMPA receptor"
Reactome:R-HSA-9619125 "CaMKK phosphorylates CAMK4"
Reactome:R-HSA-9619355 "CaMKK autophosphorylates in the cytosol"
Reactome:R-HSA-9619367 "CaMKKs phosphorylate CAMK1"
Reactome:R-HSA-9619478 "CAMKK2 phosphorylates AMPK"
Reactome:R-HSA-9619783 "CAMK1 phosphorylates ARHGEF7-1"