FlyBase Allele Report: Dmel\Drak[UAS.cCa]

General Information

Symbol

Dmel\Drak^UAS.cCa

Species

D. melanogaster

Name

UAS construct a of Chen

FlyBase ID

FBal0350373

Feature type

allele

Associated gene

Dmel\Drak

Associated Insertion(s)

Carried in Construct

P{UAS-Drak.C}

Key Links

Transgenic product class

cDNA

(Chen et al., 2019)

wild_type

(Chen et al., 2019)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Chen et al., 2019)

wild_type

(Chen et al., 2019)

Mutagen

in vitro construct

(Chen et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-Drak.C}

Cytology

Description

UASt regulates expression of the RE12147 Drak cDNA.

(Chen et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Drak

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates high grade glioma

modeled by btl::Egfr^λ.UAS

(Chen et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Drak^UAS.cCa, Scer\GAL4^repo.PU is an enhancer of hyperplasia | third instar larval stage phenotype of Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^UAS.cCa, Scer\GAL4^repo.PU is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^UAS.cCa, Scer\GAL4^repo.PU is an enhancer of hyperplasia | third instar larval stage phenotype of Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU

(Chen et al., 2019)

Other

Statement

Reference

Drak^UAS.cCa, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS has neoplasia | third instar larval stage phenotype

(Chen et al., 2019)

Drak^UAS.cCa, Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU has decreased cell number | third instar larval stage phenotype

(Chen et al., 2019)

Drak^UAS.cCa, Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU has neoplasia | third instar larval stage phenotype

(Chen et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

Drak^UAS.cCa, Scer\GAL4^repo.PU is an enhancer of larval brain | third instar larval stage phenotype of Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^UAS.cCa, Scer\GAL4^repo.PU is an enhancer of larval brain neuropil glial cell | third instar larval stage phenotype of Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^UAS.cCa, Scer\GAL4^repo.PU is an enhancer of larval brain | third instar larval stage phenotype of Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU

(Chen et al., 2019)

Drak^UAS.cCa, Scer\GAL4^repo.PU is an enhancer of larval brain neuropil glial cell | third instar larval stage phenotype of Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU

(Chen et al., 2019)

Other

Statement

Reference

Drak^UAS.cCa, Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU has larval neuron | third instar larval stage phenotype

(Chen et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expressing Drak^UAS.cCa enhances the larval brain glia hyperplasia induced by the expression of either btl::Egfr^λ.UAS or Hsap\EGFR^Δ.UAS under the control of Scer\GAL4^repo.PU; glia cells lose the normal stellate shape and form abnormal cellular aggregates that disrupted normal larval brain architecture, indicative of neoplastic transformation. The Drak^UAS.cCa, Hsap\EGFR^Δ.UAS co-expression also induces a decrease in the number of neurons.

(Chen et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Drak^UAS.cCa

Name Synonyms

UAS construct a of Chen

Secondary FlyBase IDs

References (1)

Report Sections

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