FlyBase Allele Report: Dmel\mbt[P3]

General Information

Symbol

Dmel\mbt^P3

Species

D. melanogaster

Name

FlyBase ID

FBal0218872

Feature type

allele

Associated gene

Dmel\mbt

Associated Insertion(s)

P{lacW}mbt^P3

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Menzel et al., 2007)

Mutagen

Progenitor genotype

Associated Insertion(s)

P{lacW}mbt^P3

Cytology

Description

P{lacW}mbt^P3 is inserted in the 5' untranslated region of the mbt transcription unit, 265 bp upstream of the ATG translation start codon.

(Menzel et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Menzel et al., 2007)

visible | recessive

(Menzel et al., 2007)

Phenotype Manifest In

rhabdomere & eye photoreceptor cell

(Menzel et al., 2007)

Detailed Description

Statement

Reference

mbt^P3 hemizygous males have a weak rough eye phenotype: There are mild defects in the arrangement and morphology of rhabdomeres and in some ommatidia lack a single photoreceptor cell.

(Menzel et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

mbt^P3 has eye phenotype, enhanceable by cno²/cno[+]

(Menzel et al., 2007)

mbt^P3 has eye phenotype, enhanceable by cno⁰⁰⁹¹⁰⁵/cno[+]

(Menzel et al., 2007)

mbt^P3 has eye phenotype, enhanceable by LIMK1²/LIMK1[+]

(Menzel et al., 2007)

Suppressed by

Statement

Reference

mbt^P3 has eye phenotype, suppressible by tsr[+]/tsr^k05633

(Menzel et al., 2007)

mbt^P3 has eye phenotype, suppressible by tsr[+]/tsr^N96A

(Menzel et al., 2007)

mbt^P3 has eye phenotype, suppressible by ssh^1-11/ssh[+]

(Menzel et al., 2007)

mbt^P3 has eye phenotype, suppressible by ssh^1-63/ssh[+]

(Menzel et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The mild rough eye phenotype seen in mbt^P3 hemizygous males is enhanced by cno²/+, cno⁰⁰⁹¹⁰⁵/+ or LIMK1²/+ and is suppressed by tsr^k05633/+, tsr^N96A, ssh^1-11/+ or ssh^1-63/+.

(Menzel et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mbt^P3

(Menzel et al., 2007)

mbt^P3

(Walther et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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