FlyBase Allele Report: Dmel\LIMK1[2]

General Information

Symbol

Dmel\LIMK1²

Species

D. melanogaster

Name

FlyBase ID

FBal0194763

Feature type

allele

Associated gene

Dmel\LIMK1

Associated Insertion(s)

Carried in Construct

Also Known As

Limk²

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Ang et al., 2006)

Progenitor genotype

P{EP}Pits^EP1313

(Ang et al., 2006)

Cytology

Description

Imprecise excision of the P{EP} element resulting in deletion of most of the LIMK1 gene, except exon 1 and the 5' regulatory sequences.

(Ang et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Ang et al., 2006)

viable

(Ang et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

LIMK1² is a suppressor | partially of increased size | adult stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1² is a suppressor | partially of visible | adult stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1² is a suppressor of visible | adult stage phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

LIMK1²/LIMK1² is an enhancer of eye phenotype of mbt^P1

(Menzel et al., 2007)

LIMK1²/LIMK1[+] is an enhancer of eye phenotype of mbt^P3

(Menzel et al., 2007)

Suppressor of

Statement

Reference

LIMK1² is a suppressor | partially of adult head phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1² is a suppressor of filamentous actin | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1² is a suppressor of eye disc | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1² is a suppressor of eye disc | somatic clone | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^Act.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1² is a suppressor of filamentous actin | somatic clone | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^Act.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1² is a suppressor of eye phenotype of Hsap\TTR^{V30M.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Oliveira da Silva et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

LIMK1²/+ slightly enhances the rough eye phenotype due to mbt^P3/Y. LIMK1²/LIMK1² strongly enhances the rough eye phenotype see in mbt^P1/Y animals.

(Menzel et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

59033

w^* LIMK1²

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

LIMK1²

(Jacobs et al., 2025, Farrell et al., 2022)

Limk1²

(Oliveira da Silva et al., 2020)

Limk²

(Menzel et al., 2007, Ang et al., 2006)

limk1²

(Deichsel et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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