FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mbtH19,22L.UAS
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General Information
Symbol
Dmel\mbtH19,22L.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0147018
Feature type
allele
Associated gene
Dmel\mbt
Associated Insertion(s)
Carried in Construct
P{UAS-mbt.H19,22L}
Also Known As
UAS-mbtH19,22L
Key Links
Transgenic product class
missense_variant
(Schneeberger and Raabe, 2003)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Schneeberger and Raabe, 2003)
Mutagen
in vitro construct
(Schneeberger and Raabe, 2003)
Progenitor genotype
Carried in construct
P{UAS-mbt.H19,22L}
Cytology
Description

UASt sequences drive expression of a mutated form of mbt (carries the amino acid replacements H19L and H22L).

(Schneeberger and Raabe, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mbt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing mbtH19,22L.UAS under the control of Scer\GAL4hs.2sev in an mbtP1/mbtP1 background leads to the formation of a significant proportion of elongated CadN-immunopositive adherens junctions between photoreceptor precursor cells R3 and R4 in row 5 ommatidia of wandering third instar larvae.

      (Pütz, 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      mbtH19,22L.UAS/Scer\GAL4hs.2sev partially rescues mbtP1

      (Pütz, 2019)
      Fails to rescue

      Scer\GAL4238Y/mbtH19,22L.UAS fails to rescue mbtP1

      (Schneeberger and Raabe, 2003)
      Comments

      Expressing mbtH19,22L.UAS under the control of Scer\GAL4hs.2sev partially rescues the shortened adherens junction phenotype between photoreceptor precursor cells R3 and R4 in row 5 ommatidia of mbtP1/mbtP1 wandering third instar larvae. Adherens junctions have variable lengths from slightly shorter to wild-type to lengthened.

      (Pütz, 2019)

      mbtH19,22L.Scer\UAS driven by Scer\GAL4238Y fails to rescue the eye and eye disc phenotypes seen in mbtP1 mutants.

      (Schneeberger and Raabe, 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mbtH19,22L.Scer\UAS
      mbtH19,22L.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)