Hellmich, M.R., Kennison, J.A., Hampton, L.L., Battey, J.F. (1994). Cloning and characterization of the Drosophila melanogaster CDK5 homolog. FEBS Lett. 356(2-3): 317--321.
FlyBase ID
FBrf0076476
Publication Type
Research paper
Abstract
The D. melanogaster homolog of mammalian CDK5 has been cloned and its chromosomal location determined. The gene for Cdk5 consists of 4 exons separated by 3 short introns ranging in size from 61-160 bp. Northern blot analysis revealed a single mRNA of approximately 1.6 kb that is expressed at highest levels in the adult fly. The putative amino acid sequence for Drosophila Cdk5 predicts a protein with a mass of approximately 32 kDa that is 77% identical to its mammalian counter-parts. Drosophila Cdk5 gene is located in polytene chromosomal region 52BC of the right arm of chromosome 2. This study provides the framework for a molecular genetic analysis of CDK5 function.
