Cdk43/Cdk4k06503 completely suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.
The weak segmentation defects of embryos derived from mothers carrying hop25 germ-line clones are enhanced when these mothers are heterozygous for Cdk43 : this is particularly noticeable for denticle belts A4 and A5 which are lost completely in such embryos. None of these embryos hatch. Survival to adulthood of hopTum/+ females raised at 29oC is restored to 96% wild-type levels by heterozygosity for Cdk43.
Expression of ptcScer\UAS.cCa under the control of Scer\GAL4Act5C.PP does not significantly reduce the size of clones induced in the wing disc in a Cdk43 mutant background. Expression of ciScer\UAS.cDa under the control of Scer\GAL4Act5C.PP does not significantly increase the size of clones induced in the wing disc in a Cdk43 mutant background.
The wing overgrowth phenotype caused by expression of banEP3622 under the control of Scer\GAL4Bx-MS1096 is not altered by Cdk43/Cdk43. The eye phenotype caused by expression of exScer\UAS.cBa under the control of Scer\GAL4hs.2sev is not altered by Cdk43/+.
The addition of Cdk4Scer\UAS.cMa driven by Scer\GAL4da.G32 rescues the weight, body and cell size phenotypes seen in Cdk43 flies. Whilst similar expression of Cdk4D175N.Scer\UAS.T:Hsap\MYC has no effect. Heterozygosity in CycEunspecified is tolerated in Cdk43 heterozygotes, but leads to complete lethality in Cdk43 homozygotes. Cdk43 homozygotes also heterozygous for Rbf11 (and probably Rbf14) are found to be significantly more fertile than Cdk43 homozygotes alone.