Open Close
General Information
Symbol
Dmel\Cdk4k06503
Species
D. melanogaster
Name
FlyBase ID
FBal0064432
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)k06503
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{lacW} insertion is in the second exon of the translated region of the Cdk4 gene.

P{lacW} insertion in the third intron of Cdk4.

Insertion components
P{lacW}Cdk4k06503
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Heterozygous Cdk4k06503 ameliorates the neoplasia seen in the btl::EgfrScer\UAS.T:λ\cI-DD, Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX brain glioma model when in combination with Cdk43.

Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cdk43/Cdk4k06503 mutant larval brains have normal gross morphology and glial cell numbers.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

Cdk4k06503 is a non-enhancer of visible phenotype of upd1GMR.PB

Suppressor of
NOT Suppressor of
Statement
Reference

Cdk4k06503/Cdk4[+] is a non-suppressor of increased cell death phenotype of shtd1

Cdk4k06503 is a non-suppressor of visible phenotype of upd1GMR.PB

Phenotype Manifest In
NOT Enhancer of
Statement
Reference

Cdk4k06503/Cdk4[+] is a non-enhancer of wing phenotype of pydtam/pydex147

Cdk4k06503 is a non-enhancer of eye phenotype of upd1GMR.PB

Suppressor of
NOT Suppressor of
Statement
Reference

Cdk4k06503/Cdk4[+] is a non-suppressor of eye phenotype of shtd1

Cdk4k06503/Cdk4[+] is a non-suppressor of ommatidium phenotype of shtd1

Cdk4k06503 is a non-suppressor of eye phenotype of upd1GMR.PB

Additional Comments
Genetic Interactions
Statement
Reference

Wings from pydex147/pydtam flies are broader compared to control wings, and this phenotype is not modified in a Cdk4k06503/+ background.

Cdk43/Cdk4k06503 completely suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (8)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)