FlyBase Allele Report: Dmel\CycA[unspecified]

General Information

Symbol

Dmel\CycA^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0097376

Feature type

allele

Associated gene

Dmel\CycA

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval longitudinal connective

(Hummel et al., 1999)

presumptive embryonic/larval central nervous system

(Hummel et al., 1999)

symmetrical commissure

(Hummel et al., 1999)

Detailed Description

Statement

Reference

Severe reduction in axonal growth in the embryonic CNS. Commissures and longitudinal connectives are both affected.

(Hummel et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

CycA^unspecified is a non-enhancer of visible phenotype of Wee1^GMR.PP

(Price et al., 2002)

CycA^unspecified is a non-enhancer of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

CycA^unspecified is a non-enhancer of viable phenotype of Cdk4³

(Meyer et al., 2000)

Suppressor of

Statement

Reference

CycA^unspecified/CycB^unspecified is a suppressor of lethal | maternal effect | embryonic stage phenotype of mei-41^D5/mei-41^D3

(Sibon et al., 1999)

CycA^unspecified is a suppressor of lethal | recessive | maternal effect | embryonic stage phenotype of mei-41^D3

(Sibon et al., 1999)

NOT Suppressor of

Statement

Reference

CycA^unspecified is a non-suppressor of abnormal cytokinesis phenotype of Scer\GAL4^Bx-MS1096, pbl^{ΔDH497-549.UAS}

(Echard and O'Farrell, 2003)

CycA[+]/CycA^unspecified is a non-suppressor of abnormal mitotic cell cycle phenotype of enc^unspecified

(Ohlmeyer and Schupbach, 2003)

CycA^unspecified is a non-suppressor of visible phenotype of Myt1^GMR.PP

(Price et al., 2002)

CycA^unspecified is a non-suppressor of visible phenotype of Wee1^GMR.PP

(Price et al., 2002)

CycA^unspecified is a non-suppressor of viable phenotype of Cdk4³

(Meyer et al., 2000)

Other

Statement

Reference

CycA^unspecified, dup^unspecified has decreased occurrence of cell division | embryonic stage phenotype

(Jacobs et al., 2001)

CycA^unspecified, mei-41^D5 has lethal | recessive | maternal effect | embryonic stage phenotype

(Sibon et al., 1999)

CycA^unspecified, CycB^unspecified, mei-41^D5/mei-41^D3 has lethal | maternal effect | embryonic stage phenotype

(Sibon et al., 1999)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

CycA[+]/CycA^unspecified is a non-enhancer of genitalia phenotype of dally⁰⁶⁴⁶⁴

(Nakato et al., 2002)

CycA^unspecified is a non-enhancer of eye phenotype of Wee1^GMR.PP

(Price et al., 2002)

CycA^unspecified is a non-enhancer of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

Suppressor of

Statement

Reference

CycA[+]/CycA^unspecified is a suppressor of egg chamber phenotype of twin^ry3

(Morris et al., 2005)

NOT Suppressor of

Statement

Reference

CycA^unspecified is a non-suppressor of wing hair | increased number phenotype of Scer\GAL4^Bx-MS1096, pbl^{ΔDH497-549.UAS}

(Echard and O'Farrell, 2003)

CycA[+]/CycA^unspecified is a non-suppressor of egg chamber phenotype of enc^unspecified

(Ohlmeyer and Schupbach, 2003)

CycA[+]/CycA^unspecified is a non-suppressor of genitalia phenotype of dally⁰⁶⁴⁶⁴

(Nakato et al., 2002)

CycA^unspecified is a non-suppressor of eye phenotype of Myt1^GMR.PP

(Price et al., 2002)

CycA^unspecified is a non-suppressor of eye phenotype of Wee1^GMR.PP

(Price et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of the degrading egg chamber phenotype seen in twin^ry3 hemizygotes is markedly suppressed by CycA^unspecified/+.

(Morris et al., 2005)

The extra mitotic division phenotype seen in the egg chambers of enc^unspecified females at 25^oC is not suppressed by CycA^unspecified/+. The extra mitotic division phenotype seen in the egg chambers of enc^unspecified females at 25^oC is partially suppressed by rux^hs.PT; only 25% of egg chambers contain 32 cells. This suppression of enc^unspecified by rux^hs.PT is not significantly altered if the females also carry CycA^unspecified/+.

(Ohlmeyer and Schupbach, 2003)

The fraction of embryos derived from lok^E51 females which have abnormal nuclei (61.5 +/- 1.1%) is only slightly altered (to 52.2 +/- 1.6%) if the females also carry one copy of CycA^unspecified.

(Xu and Du, 2003)

In dup^unspecified, CycA^unspecified double mutant embryos, the great majority of epidermal cells fail to enter mitosis 16.

(Jacobs et al., 2001)

The addition of CycA^unspecified, CycB^unspecified, CycB3^unspecified or cdc2^unspecified have no effect on survival of Cdk4³ homozygotes.

(Meyer et al., 2000)

The lethality of embryos derived from mei-41^D3/mei-41^D5 females is partly rescued if the females are also heterozygous for CycA^unspecified, and greater rescue is seen if the females are also heterozygous for both CycA^unspecified and CycB^unspecified.

(Sibon et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

CycA^unspecified is partially rescued by Scer\GAL4^prd.RG1/CycA^δ1-53.UAS

(Jacobs et al., 2001)

CycA^unspecified is partially rescued by Scer\GAL4^prd.RG1/CycA^δ1-83.UAS

(Jacobs et al., 2001)

CycA^unspecified is partially rescued by Scer\GAL4^prd.RG1/CycA^δ1-38.UAS

(Jacobs et al., 2001)