FlyBase Allele Report: Dmel\dup[unspecified]

General Information

Symbol

Dmel\dup^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0101447

Feature type

allele

Associated gene

Dmel\dup

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | maternal effect

(Parry et al., 2003)

decreased occurrence of cell division | embryonic stage | maternal effect

(Parry et al., 2003)

Phenotype Manifest In

kinetochore | maternal effect

(Parry et al., 2003)

S phase

(Jacobs et al., 2001)

Detailed Description

Statement

Reference

When a maternal supply of dup is depleted, replication fails mutant embryos and cells accumulate in mitosis. Chromosomes also make oscillatory movements between the poles. Chromosomes are scattered along the spindle, with some clustering in a central pseudometaphase plate, despite the presence of only a single kinetochore. Merotelic attachments are seen: kinetochore fibres from both poles are seen to impinge on single kinetochores.

(Parry et al., 2003)

Mutant embryos fail to enter S phase 16, but do go on to enter mitosis 16.

(Jacobs et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CycA^unspecified, dup^unspecified has decreased occurrence of cell division | embryonic stage phenotype

(Jacobs et al., 2001)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

dup^unspecified is a non-enhancer of phenotype of png^unspecified

(Lee et al., 2001)

NOT Suppressor of

Statement

Reference

dup^unspecified is a non-suppressor of phenotype of png^unspecified

(Lee et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

In dup^unspecified, CycA^unspecified double mutant embryos, the great majority of epidermal cells fail to enter mitosis 16.

(Jacobs et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dup^PA77

(Orr-Weaver, 1999.10.30)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dup^unspecified

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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