FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CycAδ1-53.UAS
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General Information
Symbol
Dmel\CycAδ1-53.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0124345
Feature type
allele
Associated gene
Dmel\CycA
Associated Insertion(s)
Carried in Construct
P{UAS-CycA.δ1-53}
Key Links
Transgenic product class
inframe_deletion
(Jacobs et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Jacobs et al., 2001)
Mutagen
in vitro construct
(Jacobs et al., 2001)
Progenitor genotype
CycAUAS.cWa
(Jacobs et al., 2001)
Carried in construct
P{UAS-CycA.δ1-53}
Cytology
Description

Amino acids 1-53 have been deleted.

(Jacobs et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
CycA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CycAδ1-53.Scer\UAS Scer\GAL4prd.RG1 extended germ band stage embryos have increased numbers of mitotic developing epidermal cells in expressing segments compared to non-expressing segments.

      (Leismann and Lehner, 2003)

      When two copies of CycAα1-53.Scer\UAS is driven by Scer\GAL4prd.RG1, significant mitotic delay (probably starting during metaphase) is observed. When CycAα1-31,39-44.Scer\UAS is driven by Scer\GAL4prd.RG1 a slight delay in mitosis 16 is seen. An extra S phase is detected (by BrDU incorporation) followed by an extra M phase. This division is aberrant.

      (Jacobs et al., 2001)

      When two copies of CycAδ1-53.Scer\UAS is driven by Scer\GAL4prd.RG1, significant mitotic delay (probably starting during metaphase) is observed. When CycAδ1-31,39-44.Scer\UAS is driven by Scer\GAL4prd.RG1 a slight delay in mitosis 16 is seen. An extra S phase is detected (by BrDU incorporation) followed by an extra M phase. This division is aberrant.

      (Jacobs et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      pimg.dba.T:Hsap\MYC enhances the increase in mitotic cells see in expressing segements of CycAδ1-53.Scer\UAS Scer\GAL4prd.RG1 extended germ band stage embryos.

      (Leismann and Lehner, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4prd.RG1/CycAδ1-53.UAS partially rescues CycAunspecified

      (Jacobs et al., 2001)
      Comments

      The addition of this mutant transgene to CycAunspecified mutants allows the progression into mitosis 16, although it also results in enrichment of metaphase figures and frequently interferes with successful completion of cell division.

      (Jacobs et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CycAα1-53.Scer\UAS
      CycAδ1-53.Scer\UAS
      CycAδ1-53.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)