FB2026_03 , released September 17, 2026
Allele: Dmel\pimkenadba.g.Tag:MYC
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General Information
Symbol
Dmel\pimkenadba.g.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0240395
Feature type
allele
Associated gene
Dmel\pim
Associated Insertion(s)
Carried in Construct
P{g(-FRT)pim.kenadba.MYC}
Key Links
Transgenic product class
missense_variant
(Leismann and Lehner, 2003)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Leismann and Lehner, 2003)
Mutagen
FLPase
(Leismann and Lehner, 2003)
Progenitor genotype
pimkenadba.g.FRT.Tag:MYC
(Leismann and Lehner, 2003)
Carried in construct
P{g(-FRT)pim.kenadba.MYC}
Cytology
Description

pim promoter sequences drive expression of a mutated pim ORF and 3'UTR; the destruction box has been mutated from KKPLGNLDN to AKPAGNLDA and the KEN motif found near the N-terminal end of the coding sequence has been mutated to AAA. The coding sequence is tagged with Tag:MYC. Generated by excision of the FRT stop cassette from pimkenadba.g.FRT.Tag:MYC.

(Leismann and Lehner, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
pim
Encoded product / tool
pim
Tagged with
Tag:MYC
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cell division is normal during early embryogenesis in pimkenadba.g.T:Hsap\MYC embryos, but by stage 14, the CNS contains many large polyploid cells - indicating inhibition of mitosis.

      (Leismann and Lehner, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      pimkenadba.g.Tag:MYC fails to rescue pimIL

      (Leismann and Lehner, 2003)
      Comments

      Inhibition of sister chromatid separation during mitosis 15 in pimIL/pimIL embryos (from pimIL/+ mothers) is not rescued by pimkenadba.g.T:Hsap\MYC.

      (Leismann and Lehner, 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pimkenadba.g.T:Hsap\MYC
      pimkenadba.g.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)