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FB2026_01
,
released March 12, 2026
Spider, ms(3)89B, Hrr25, CK1γ, CKIγ
Casein kinase 1 γ homolog - interacts Arrow to modify Wingless signaling - mutants show a defect in spermatid individualization - required to potentiate Wingless signaling in limb development - acts in the posterior region of the eye disc to prevent precocious glial cell migration
Please see the JBrowse view of Dmel\gish for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 6.02
Gene model reviewed during 6.32
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gish using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: only gish-RB and gish-RF observed
Of the 13 predicted gish transcripts, only gish-RB and gish-RF were detected in testis using primer pairs specific to each transcript species.
JBrowse - Visual display of RNA-Seq signals
View Dmel\gish in JBrowse3-58
3-58.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells and/or aneuploidy, an increase in the proportion of G2/M phase cells, and increase in in mitotic index, and spindle abnormalities are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Area matching Drosophila EST AA949934. This EST has sequence similarity to mammalian Casein kinase genes.
gish may be part of a repulsive signaling mechanism coordinating glial migration and neuronal development in the developing eye.
In mutants, glial cells prematurely migrate into the ectopic positions anterior to the photoreceptors. As a consequence, a subset of photoreceptor axons projects anteriorly, suggesting an instructive role for the glial cells in axon pathfinding. Furthermore, gish mutant glial cells also inappropriately adhere to and migrate along Bolwigs nerve.
Postmeiotic differentiation defect.
Source for merge of: CKI-related CG6963
Source for merge of: gish anon-WO0118547.425
Source for merge of: gish NEST:bs27c08
Source for merge of gish anon-WO0118547.425 was sequence comparison ( date:051113 ).
Source for identity of: gish CKI-related
