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General Information
Symbol
Dmel\gishKG03891
Species
D. melanogaster
Name
FlyBase ID
FBal0130262
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion in the third exon.

Insertion components
P{SUPor-P}gishKG03891
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

gish04895/gishKG03891 as well as gishMI08417/gishKG03891 transheterozygous mutant males show decreased average number of germline stem cells in their testes already at post-eclosion day 1 and as the flies age the GSCs continue to be lost at a rapid rate, this however is not due to excessive apoptosis and neither do the mutant GSCs lose their adhesion to the hub cells as shown in gishMI08417/gishKG03891 males.

No significant difference in the number of GSCs is observed in gishKG03891 heterozygotes, as compared to wild-type controls.

Homozygotes show strong, but incomplete lethality.

Heterozygotes show a significant impairment in 3 minute, 30 minute and 3 hour memory after olfactory conditioning compared to wild-type flies.

Heterozygotes and homozygotes show normal shock and odour avoidance.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

gish[+]/gishKG03891 is a non-suppressor of visible phenotype of Scer\GAL4Bx-MS1096, smoPKA12.UAS

gish[+]/gishKG03891 is a non-suppressor of bang sensitive | semidominant phenotype of parabss1

Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

gish[+]/gishKG03891 is a non-suppressor of wing phenotype of Scer\GAL4Bx-MS1096, smoPKA12.UAS

Additional Comments
Genetic Interactions
Statement
Reference

gishKG03891/+ does not modify the fused wing phenotype of flies expressing smoPKA12.Scer\UAS under the control of Scer\GAL4Bx-MS1096, but the presence of gishKG03891/gishKG03891 clones in the wings of flies expressing smoPKA12.Scer\UAS under the control of Scer\GAL4Bx-MS1096 leads to a greatly enhanced fused wing phenotype.

The bang sensitive phenotype seen in parabss1/+ mutant females is not suppressed by one copy of gishKG03891.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The age-progressive loss of germline stem cells in adult male testes observed in gish04895/gishKG03891 as well as gishMI08417/gishKG03891 transheterozygotes is fully rescued by combination with gishgish.F. Similarly, combination with gishnos.F also rescues the phenotype in gishMI08417/gishKG03891 mutants and both gish04895/gishKG03891 and gish04895/gishMI08417 mutants can be rescued by expression of gishScer\UAS.P\T.F under the control of Scer\GAL4nos.UTR.T:Hsim\VP16, while Scer\GAL4C587-driven expression fails to rescue the gishMI08417/gishKG03891 mutants.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)