FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pblUAS.Tag:HA
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General Information
Symbol
Dmel\pblUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0263871
Feature type
allele
Associated gene
Dmel\pbl
Associated Insertion(s)
Carried in Construct
P{UAS-pbl.HA}
Key Links
Transgenic product class
cDNA
(van Impel et al., 2009)
wild_type
(van Impel et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(van Impel et al., 2009)
wild_type
(van Impel et al., 2009)
Mutagen
in vitro construct
(van Impel et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-pbl.HA}
Cytology
Description

UASt regulatory sequences drive expression of full length pbl-RA cDNA (853 amino acids) which is tagged at the C-terminal end with Tag:HA.

(van Impel et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
pbl
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4e22c-mediated expression of pblScer\UAS.T:Ivir\HA1 results in 100% embryonic lethality with 40.2% of embryos showing some loss of naked cuticle on the ventral side. Other defects include missing head structures, failure to retract the germ band and incomplete dorsal closure.

      (Greer et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4arm.PS-mediated co-expression of armS10.Scer\UAS.T:Hsap\MYC and pblScer\UAS.T:Ivir\HA1 produces severe developmental defects.

      (Greer et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      pblUAS.Tag:HA/Scer\GAL4twi.2PE rescues pbl3

      (van Impel et al., 2009)
      Partially rescues

      pblUAS.Tag:HA/Scer\GAL4twi.PG partially rescues pbl3

      (Greer et al., 2013)
      Comments

      Scer\GAL4twi.PG-mediated expression of pblScer\UAS.T:Ivir\HA1 rescues the mesoderm defects in pbl3 embryos but the ectopic naked cuticle phenotype persists.

      (Greer et al., 2013)

      Expression of pblScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4twi.2PE rescues the cytokinesis and mesodermal migration defects seen in pbl3 homozygous mutants.

      (van Impel et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pblScer\UAS.T:Ivir\HA1
      pblUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)