FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pblS008320
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General Information
Symbol
Dmel\pblS008320
Species
D. melanogaster
Name
FlyBase ID
FBal0082374
Feature type
allele
Associated gene
Dmel\pbl
Associated Insertion(s)
P{lacW}pblS008320
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Salzberg et al., 1997)
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
P-element activity
(Prokopenko et al., 1999, Szeged Stock Center, 1998-, Salzberg et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{lacW}pblS008320
Cytology
Description

P{lacW} insertion in the open reading frame of the 1A cDNA.

(Prokopenko et al., 1999)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF174650
AF174651
AF174652
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early lethal.

      (Deak et al., 1997)

      Embryos exhibit severe fasciculation defects, loss of neurons and concommitant increase in the size of the remaining cells. Mutants display gross defects in the axonal trajectories in the PNS. The intersegmental nerve grows from the dorsal cluster along aberrant pathways and often fails to connect to the lateral PNS cluster. Axons also cross segment boundaries in the dorsal, lateral and ventro-lateral region.

      (Salzberg et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{lacW} is accompanied by a reversion to wild-type.

      (Prokopenko et al., 1999)

      Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

      (Salzberg et al., 1997)
      External Crossreferences and Linkouts ( 3 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      0083/20
      (Deak et al., 1997)
      83/20
      (Salzberg et al., 1997)
      l(3)S008320
      (Prokopenko et al., 2000)
      pblP008320
      (Broihier and Skeath, 2002)
      pblS008320
      Name Synonyms
      Secondary FlyBase IDs
        References (6)