FlyBase Allele Report: Dmel\grp[KK108548]

General Information

Symbol

Dmel\grp^KK108548

Species

D. melanogaster

Name

FlyBase ID

FBal0259697

Feature type

allele

Associated gene

Dmel\grp

Associated Insertion(s)

Carried in Construct

P{KK108548}

Also Known As

UAS-grapes^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108548}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108548

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with BacA\p35^UAS.cHa

(Dekanty et al., 2015)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4^19-12

(Li et al., 2021)

Phenotype Manifest In

axon | larval stage | conditional, with Scer\GAL4^19-12

(Li et al., 2021)

larval multidendritic class III neuron | conditional, with Scer\GAL4^19-12

(Li et al., 2021)

Detailed Description

Statement

Reference

Unlike controls, individuals expressing grp^KK108548 under the control of Scer\GAL4^19-12 show increased class III da neuron axonal regeneration after injury.

(Li et al., 2021)

The expression of grp^KK108548 under the control of Scer\GAL4^ey.PH does not have an obvious effect on the adult eye size compared to controls.

(Clemente-Ruiz et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

grp^KK108548/Scer\GAL4^ey.PH is an enhancer | female of increased cell death | larval stage phenotype of Scer\GAL4^e22c, rod^GD8768

(Clemente-Ruiz et al., 2016)

grp^KK108548, Scer\GAL4^ey.PH is an enhancer | female of abnormal size | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

grp^KK108548, Scer\GAL4^ey.PH is an enhancer | female of visible phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

grp^KK108548, Scer\GAL4^en.PU is an enhancer of hyperplasia | larval stage | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

grp^KK108548/Scer\GAL4^ey.PH is an enhancer | female of wing disc posterior compartment phenotype of Scer\GAL4^e22c, rod^GD8768

(Clemente-Ruiz et al., 2016)

grp^KK108548, Scer\GAL4^ey.PH is an enhancer | female of eye phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

grp^KK108548, Scer\GAL4^en.PU is an enhancer of wing disc posterior compartment | conditional phenotype of BacA\p35^UAS.cHa, Scer\GAL4^en.PU

(Dekanty et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of grp^KK108548 enhances the enlarged wing disc posterior compartment observed upon exposure to ionizing radiation of individuals expressing BacA\p35^UAS.cHa under the control of Scer\GAL4^en.PU.

The Scer\GAL4^en.PU-driven co-expression of BacA\p35^UAS.cHa and grp^KK108548 leads to a longer sustained DNA damage response to ionizing ration (assessed by phospho-H2Av immunostaining) in the wing disc posterior compartment as compared to the BacA\p35^UAS.cHa single expression or wild-type backgrounds.

(Dekanty et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110076

P{KK108548}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

grp^KK108548

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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