FlyBase Allele Report: Dmel\grp[Z5170]

General Information

Symbol

Dmel\grp^Z5170

Species

D. melanogaster

Name

FlyBase ID

FBal0197285

Feature type

allele

Associated gene

Dmel\grp

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(LaRocque et al., 2007)

Mutagen

ethyl methanesulfonate

(LaRocque et al., 2007)

Progenitor genotype

Cytology

Description

Amino acid replacement: P189L.

(LaRocque et al., 2007)

Nucleotide substitution: C?T.

(LaRocque et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:16,697,560..16,697,560 [+]

Nucleotide change:

C16697560T

Reported nucleotide change:

C?T

Amino acid change:

Reported amino acid change:

P189L

(LaRocque et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

spindle

(Rickmyre et al., 2007)

spindle (with Df(2L)H20)

(Rickmyre et al., 2007)

Detailed Description

Statement

Reference

Homozygous eye discs show severe defects in hydroxyurea-induced G2 arrest, with the number of mitotic cells remaining high after treatment, in contrast to wild type.

(Lee et al., 2012)

The mitotic checkpoint normally induced by 4000rad of irradiation is not detectable in grp²⁰⁹/grp^Z5170 mutants. No checkpoint is detectable in these animals after irradiation with 500rad.

grp²⁰⁹/grp^Z5170 males in which excision of insertions of P{hsw^a} is induced during development are completely viable.

(LaRocque et al., 2007)

32.8% of embryos derived from grp^Z5170/Df(2L)H20 females and 21.4% of embryos derived from homozygous grp^Z5170 females arrest in precortical cycles with acentrosomal, barrel-shaped spindles.

(Rickmyre et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

grp^Z5170 has chemical sensitive phenotype, enhanceable by lok³⁰

(Lee et al., 2012)

Other

Statement

Reference

E(mus304)[+]/PolA1^Emus304, grp²⁰⁹/grp^Z5170 has visible | male limited phenotype

(LaRocque et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

grp²⁰⁹/grp^Z5170, lok³⁰/lok³⁰ is a suppressor | partially of embryo phenotype of Pp1α-96A², Pp1-87B^87Bg-3

(Deneke et al., 2019)

grp²⁰⁹/grp^Z5170, lok³⁰/lok³⁰ is a suppressor of embryo phenotype of Cul5^GM163/Cul5^GM130

(Deneke et al., 2019)

Other

Statement

Reference

E(mus304)[+]/PolA1^Emus304, grp²⁰⁹/grp^Z5170 has eye | male limited phenotype

(LaRocque et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

lok³⁰ increases the severity of the defect in hydroxyurea-induced G2 arrest which is seen in grp^Z5170 eye discs.

(Lee et al., 2012)

Survival to adulthood of grp²⁰⁹/grp^Z5170 lok³⁰ males in which excision of an insertion of P{hsw^a} is induced during development is drastically reduced.

(LaRocque et al., 2007)

grp²⁰⁹/grp^Z5170 ; DNApol-α180^Emus304/+ males have a rough eye phenotype, while grp²⁰⁹/grp^Z5170 ; DNApol-α180^Emus304/+ females have wild-type eyes. The wing discs of these mutant animals show an increase in apoptosis compared to wild type.

(LaRocque et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

grp⁰⁶⁰³⁴

(LaRocque et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ZII-5170

(Rickmyre et al., 2007)

grp^Z5170

(Lee et al., 2012, LaRocque et al., 2007, LaRocque et al., 2007, Rickmyre et al., 2007)

grp^z5170

(Ferree et al., 2022, Hayden et al., 2022, Hur et al., 2020, Deneke et al., 2019, Deneke et al., 2016, Di Talia et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

Open Close