FlyBase Allele Report: Dmel\lok[30]

General Information

Symbol

Dmel\lok³⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0197286

Feature type

allele

Associated gene

Dmel\lok

Associated Insertion(s)

Carried in Construct

Also Known As

chk2^P30, lok^P30

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(LaRocque et al., 2007)

Progenitor genotype

P{EPgy2}EY15840

(LaRocque et al., 2007)

Cytology

Description

Intragenic deletion within lok. Breakpoints are 2L:20061478..2061479 ; 2L:20062427..20062428 .

(Geyer, 2026.3.25)

Imprecise excision of the P{EPgy2}EY15840 insertion, resulting in a deletion of the 5' UTR and first two coding exons of lok.

(LaRocque et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Nestor-Guillermo progeria syndrome

modeled by baf^gfpA13T

(Duan et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

lok³⁰ ameliorates phenotype of baf^gfpA13T when in trans to lok^p6.

(Duan et al., 2023)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The mitotic checkpoint normally induced by 4000rad of irradiation is decreased in lok³⁰ mutants. The checkpoint response at 500rad of irradiation is not affected in these mutants.

lok³⁰ males in which excision of insertions of P{hsw^a} is induced during development are completely viable.

(LaRocque et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

lok³⁰ is an enhancer of chemical sensitive phenotype of grp^Z5170

(Lee et al., 2012)

Other

Statement

Reference

E(mus304)[+]/PolA1^Emus304, lok³⁰ has increased cell death phenotype

(LaRocque et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

grp²⁰⁹/grp^Z5170, lok³⁰/lok³⁰ is a suppressor | partially of embryo phenotype of Pp1α-96A², Pp1-87B^87Bg-3

(Deneke et al., 2019)

grp²⁰⁹/grp^Z5170, lok³⁰/lok³⁰ is a suppressor of embryo phenotype of Cul5^GM163/Cul5^GM130

(Deneke et al., 2019)

Other

Statement

Reference

E(mus304)[+]/PolA1^Emus304, lok³⁰ has wing disc phenotype

(LaRocque et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

lok³⁰ increases the severity of the defect in hydroxyurea-induced G2 arrest which is seen in grp^Z5170 eye discs.

(Lee et al., 2012)

Survival to adulthood of grp²⁰⁹/grp^Z5170 lok³⁰ males in which excision of an insertion of P{hsw^a} is induced during development is drastically reduced.

(LaRocque et al., 2007)

The eyes of lok³⁰ ; DNApol-α180^Emus304/+ flies are indistinguishable from wild type. The wing discs of these animals show a slight increase in apoptosis compared to wild type.

(LaRocque et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

chk2^P30

(Kitzman et al., 2022)

chk2^p30

(Jones et al., 2024, Duan et al., 2023, Cui et al., 2021)

lok³⁰

(Geyer, 2026.3.25, Ferree et al., 2022, Hayden et al., 2022, Hur et al., 2020, Deneke et al., 2019, Deneke et al., 2016, Di Talia et al., 2013, Lee et al., 2012, LaRocque et al., 2007, LaRocque et al., 2007)

lok^P30

(Easwaran et al., 2022, Duan et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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