FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cul5GM163
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General Information
Symbol
Dmel\Cul5GM163
Species
D. melanogaster
Name
FlyBase ID
FBal0154599
Feature type
allele
Associated gene
Dmel\Cul5
Associated Insertion(s)
Carried in Construct
Also Known As
shklGM163
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Yohn et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: W51term.

(Hayden et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:29,062,663..29,062,663 [-]
Nucleotide change:

G29062663A

Reported nucleotide change:

G?A

Amino acid change:

W51term | Cul5-PA

Reported amino acid change:

W51term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Hayden et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      shklGM130/shklGM163 embryos exhibit a nonuniform distribution of nuclei along AP axis and a significant degree of asynchrony, which increased during blastoderm divisions when compared to controls.

      (Deneke et al., 2019)

      Embryos resulting from shklGM45 germ-line clones or laid by shklGM45/shklGM163 mothers have reduced numbers of germ cells compared to wild-type embryos. At cleavage stages in these embryos, the nuclei fail to undergo proper axial expansion and as a consequence fail to reach the termini of the embryo, particularly the posterior. Dividing cleavage stage nuclei in these embryos occasionally show centrosome or chromosome loss, but mitotic synchrony appears undisturbed.

      (Yohn et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Cul5GM163/Cul5GM130 has embryo | maternal effect phenotype, suppressible by Src64B[+]/Src64Bko

      (Hayden et al., 2022)

      Cul5GM163/Cul5GM130 has nucleus | maternal effect | embryonic cycle 6 phenotype, suppressible by Src64B[+]/Src64Bko

      (Hayden et al., 2022)

      Cul5GM163/Cul5GM130 has embryo phenotype, suppressible by grp209/grpZ5170, lok30/lok30

      (Deneke et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cul5GM163
      shklGM163
      (Hayden et al., 2022, Deneke et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)