FlyBase Allele Report: Dmel\grp[JF02588]

General Information

Symbol

Dmel\grp^JF02588

Species

D. melanogaster

Name

FlyBase ID

FBal0239288

Feature type

allele

Associated gene

Dmel\grp

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02588}

Also Known As

Chk1 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.8.10)

Mutagen

in vitro construct

(Perkins et al., 2009.8.10)

Progenitor genotype

Carried in construct

P{TRiP.JF02588}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.8.10)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02588

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}

(Taylor et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4^19-12

(Li et al., 2021)

decreased occurrence of cell division | conditional, with Scer\GAL4^esg.PU, Scer\GAL4^mex1.PU

(Geng et al., 2025)

radiation sensitive, with Scer\GAL4^ap-md544

(Kondo and Perrimon, 2011)

Phenotype Manifest In

axon | larval stage | conditional, with Scer\GAL4^19-12

(Li et al., 2021)

larval multidendritic class III neuron | conditional, with Scer\GAL4^19-12

(Li et al., 2021)

midgut | conditional, with Scer\GAL4^esg.PU, Scer\GAL4^mex1.PU

(Geng et al., 2025)

Detailed Description

Statement

Reference

Unlike controls, individuals expressing grp^JF02588 under the control of Scer\GAL4^19-12 show increased class III da neuron axonal regeneration after injury.

(Li et al., 2021)

The expression of grp^JF02588 under the control of Scer\GAL4^ey-OK107 does not lead to any obvious olfactory learning or memory defects upon an olfactory aversive conditioning assay

(Lee et al., 2018)

X-ray irradiation of wild-type third-instar larvae induces cell cycle arrest within 1 hour. In contrast, X-ray irradiation of larvae expressing grp^JF02588 via Scer\GAL4^ap-md544 fails to induce cell cycle arrest.

(Kondo and Perrimon, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

grp^JF02588, Scer\GAL4^nanos.PU is a suppressor | partially of decreased cell number | spermatogenesis | progressive phenotype of Rtel1^HMS00770, Scer\GAL4^nanos.PU

(Yang et al., 2021)

NOT Suppressor of

Statement

Reference

grp^JF02588/Scer\GAL4^hh.PU is a non-suppressor of increased cell death | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

Phenotype Manifest In

Suppressor of

Statement

Reference

grp^JF02588, Scer\GAL4^nanos.PU is a suppressor | partially of male germline stem cell | larval stage | decreased number phenotype of Rtel1^HMS00770, Scer\GAL4^nanos.PU

(Yang et al., 2021)

NOT Suppressor of

Statement

Reference

grp^JF02588/Scer\GAL4^hh.PU is a non-suppressor of wing disc posterior compartment | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27277

y¹ v¹; P{TRiP.JF02588}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

grp^JF02588

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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