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Citation
Janic, A., Mendizabal, L., Llamazares, S., Rossell, D., Gonzalez, C. (2010). Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila.  Science 330(6012): 1824--1827.
FlyBase ID
FBrf0212713
Publication Type
Research paper
Abstract

Model organisms such as the fruit fly Drosophila melanogaster can help to elucidate the molecular basis of complex diseases such as cancer. Mutations in the Drosophila gene lethal (3) malignant brain tumor cause malignant growth in the larval brain. Here we show that l(3)mbt tumors exhibited a soma-to-germline transformation through the ectopic expression of genes normally required for germline stemness, fitness, or longevity. Orthologs of some of these genes were also expressed in human somatic tumors. In addition, inactivation of any of the germline genes nanos, vasa, piwi, or aubergine suppressed l(3)mbt malignant growth. Our results demonstrate that germline traits are necessary for tumor growth in this Drosophila model and suggest that inactivation of germline genes might have tumor-suppressing effects in other species.

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Note

Cancer. Germ cell genes and cancer.
Wu and Ruvkun, 2010, Science 330(6012): 1761--1762 [FBrf0214480]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference