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FB2026_01
,
released March 12, 2026
Please see the JBrowse view of Dmel\stil for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
1.2 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
40 (kD observed); 35.8 (kD predicted)
321 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stil using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
stil transcripts are first detected in the germarium where they are observed in all of the germ cells including the stem cells. They are present in the cytoplasm of nurse cells through most of oogenesis and reach a peak in stage S10. No staining in the oocyte is seen.
stil protein is detected in the nucleus of germ cells starting at embryonic stage 11. Expression continues to be detected in the nuclei of germ cells of both sexes in first and second larval instars. During the third larval instar, differences in staining between sexes become apparent. In females, all germ cell nuclei are stained in third instar larvae and in ovaries of adults. In adult females, oocyte nuclei stain until stage S10, while nurse cell nuclei continue to be stained until they degenerate. In males, stil protein is detected in some, but not all germ cell nuclei. In third instar larval and adult testes, expression levels are low at the tip of the testes, are high in newly formed 16-cell cysts of primary spermatocytes, but disappear thereafter.
JBrowse - Visual display of RNA-Seq signals
View Dmel\stil in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
stil has been cloned and sequenced, and its expression pattern has been analysed.
Genetic and morphological analysis of stil.
stil has a role in specifying or maintaining a cytoskeletal component that is required in the germ line during oogenesis, and possibly during germ line sex determination.
The most severe mutations produce agametic ovaries that lack germ cell clusters. Less severe mutations exhibit cell-associated cytoskeletal defects that underlie a variety of phenotypic anomalies.
Mutations in stil cause two characterisitic phenotypes: death of female germ cells and surviving germ cells show a sexual transformation and differentiate as spermatocytes.
stil is required in the female but not male germline.
Mutants exhibit reduced quantities of yolk in the oocytes due to lack of functional gene product in the germ cells.
The stil locus affects early oogenesis: mutations cause the production of few, defective germ cells.
