FlyBase Allele Report: Dmel\stil[1]

General Information

Symbol

Dmel\stil¹

Species

D. melanogaster

Name

FlyBase ID

FBal0016189

Feature type

allele

Associated gene

Dmel\stil

Associated Insertion(s)

Carried in Construct

Also Known As

stil^WE42

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Mulligan et al., 1996, Schupbach and Wieschaus, 1991)

Progenitor genotype

Cytology

Description

Amino acid replacement: K79M.

(Sahut-Barnola and Pauli, 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:12,570,760..12,570,760 [+]

Nucleotide change:

A12570760T

Amino acid change:

K79M | stil-PA

Reported amino acid change:

K79M|FBrf0108423

Comment:

site of nucleic acid difference inferred by FlyBase curator based on reported amino acid change

(Sahut-Barnola and Pauli, 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Schupbach and Wieschaus, 1991)

female sterile | recessive

(Mulligan et al., 1996)

Phenotype Manifest In

dorsal appendage

(Mulligan et al., 1996)

egg chamber

(Mulligan et al., 1996)

egg chorion

(Mulligan et al., 1996)

oocyte

(Pennetta and Pauli, 1997)

ovary

(Mulligan et al., 1996)

Detailed Description

Statement

Reference

stil¹/stil⁴ ovaries have relatively normal egg chambers, although the oocyte is often in an abnormal position. The dominant ovo^D2 phenotype is not significantly enhanced by one copy of stil¹.

(Pennetta and Pauli, 1997)

Females have rudimentary ovaries that either lack germ cells, or contain a few egg chambers with abnormal numbers of germ cells. Follicle cells function normally. Posterior migration of the follicle cells occurs normally but they secrete reduced dorsal appendages and an 'open-ended' chorion.

(Mulligan et al., 1996)

No egg chambers.

(Schupbach and Wieschaus, 1991)

female-sterile homozygous females contain few developing egg chambers in their ovaries, which may contain abnormal numbers of nurse cells and usually degenerate before yolk uptake begins.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

stil¹

stil^WE42

(Schonbaum et al., 2000, Schupbach and Wieschaus, 1991)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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