FlyBase Gene Report: Dmel\mael

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\mael

General Information

Symbol

Dmel\mael

Species

D. melanogaster

Name

maelstrom

Annotation Symbol

CG11254

Feature Type

protein_coding_gene

FlyBase ID

FBgn0016034

Gene Model Status

Stock Availability

10 publicly available

Gene Summary

Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage. Indirectly required to position the microtubule organizing center in stage 2-6 oocytes. Involved in repression of long interspersed nuclear elements (LINEs) including HeT-A, I-element, TART and possibly mst40 LINEs; may have a role in production of piwi-interacting RNA (piRNA) (PubMed:17428915). (UniProt, Q9VNS0)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:22,721,203..22,726,234 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:22721203..22726234

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (28 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables transcription cis-regulatory region binding

inferred from direct assay

(Pek et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000482813

(GO Reference Genome Project, 2011-)

Biological Process (22 terms)

Terms Based on Experimental Evidence (19 terms)

CV Term

Evidence

References

involved_in dorsal appendage formation

inferred from mutant phenotype

(Hayashi et al., 2014)

involved_in dorsal/ventral axis specification

inferred from mutant phenotype

(Clegg et al., 1997)

involved_in germ-line stem cell population maintenance

inferred from mutant phenotype

(Pek et al., 2009)

involved_in intracellular mRNA localization

inferred from mutant phenotype

(Clegg et al., 1997)

involved_in intracellular protein localization

inferred from mutant phenotype

(Pare and Suter, 2000)

involved_in microtubule organizing center organization

inferred from mutant phenotype

(Clegg et al., 2001)

involved_in miRNA metabolic process

inferred from mutant phenotype

(Findley et al., 2003)

involved_in negative regulation of DNA-templated transcription

inferred from direct assay

(Pek et al., 2009)

involved_in negative regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Chang et al., 2019)

involved_in oocyte anterior/posterior axis specification

inferred from mutant phenotype

(Clegg et al., 1997)

involved_in oocyte fate commitment

inferred from mutant phenotype

(Pek et al., 2012)

involved_in oocyte microtubule cytoskeleton organization

inferred from mutant phenotype

(Clegg et al., 1997)

involved_in oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

inferred from mutant phenotype

(Clegg et al., 1997)

involved_in oogenesis

inferred from mutant phenotype

(Clegg et al., 1997)

involved_in piRNA processing

inferred from mutant phenotype

(Lim and Kai, 2007)

involved_in regulation of pole plasm oskar mRNA localization

inferred from mutant phenotype

(Cook et al., 2004)

involved_in regulatory ncRNA-mediated gene silencing

inferred from mutant phenotype

(Lim and Kai, 2007)

involved_in spermatogenesis

inferred from mutant phenotype

(Pek et al., 2009)

involved_in transposable element silencing by piRNA-mediated heterochromatin formation

inferred from mutant phenotype

(Chang et al., 2019, Sienski et al., 2012)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

involved_in cytoskeleton organization

traceable author statement

(Johnstone and Lasko, 2001)

involved_in intracellular mRNA localization

traceable author statement

(Johnstone and Lasko, 2001)

involved_in male meiotic nuclear division

inferred from biological aspect of ancestor with PANTHER:PTN000482813

(GO Reference Genome Project, 2011-)

involved_in negative regulation of DNA-templated transcription

inferred from biological aspect of ancestor with PANTHER:PTN000482813

(GO Reference Genome Project, 2011-)

involved_in piRNA processing

inferred from biological aspect of ancestor with PANTHER:PTN000482813

(GO Reference Genome Project, 2011-)

involved_in regulation of miRNA-mediated gene silencing

inferred from electronic annotation with InterPro:IPR024970

(InterPro Project Members, 2004-)

involved_in spermatogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000482813

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Sienski et al., 2015, Findley et al., 2003)

located_in nucleus

inferred from direct assay

(Pek et al., 2009)

inferred from direct assay

(Findley et al., 2003)

is_active_in P granule

inferred from direct assay

(Huang et al., 2014)

located_in P granule

inferred from direct assay

(Patil and Kai, 2010, Findley et al., 2003)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Lim and Kai, 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000482813

(GO Reference Genome Project, 2011-)

is_active_in P granule

inferred from biological aspect of ancestor with PANTHER:PTN000482813

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the maelstrom family. (Q9VNS0)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage. Indirectly required to position the microtubule organizing center in stage 2-6 oocytes. Involved in repression of long interspersed nuclear elements (LINEs) including HeT-A, I-element, TART and possibly mst40 LINEs; may have a role in production of piwi-interacting RNA (piRNA) (PubMed:17428915).

(UniProt, Q9VNS0)

Summary (Interactive Fly)

HMG box protein - spindle class protein - potential regulator of RNA processing or subcellular localization - essential for piRNA-mediated transcriptional transposon silencing - coordinates microtubule organization during Drosophila oogenesis through interaction with components of the microtubule-organizing center

Interactive Fly

Gene Model and Products

Number of Transcripts

4

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\mael for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VNS0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

4YBG

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.43

Gene model reviewed during 5.45

Antisense UTR:

Gene model reviewed during 6.02

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0089633

1759

459

FBtr0089632

1830

459

FBtr0089631

1839

462

FBtr0347062

2143

459

Additional Transcript Data and Comments

Reported size (kB)

1.8 (northern blot)

(Clegg et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0088576

51.6

459

8.30

FBpp0088575

51.6

459

8.30

FBpp0088574

52.0

462

8.30

FBpp0312456

51.6

459

8.30

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

459 aa isoforms: mael-PA, mael-PB, mael-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

459 (aa); 48 (kD observed)

(Clegg et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

4YBG

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mael using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.57

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

(Park et al., 2011)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 11 -- 12

fat body/gonad primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 13 -- 16

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 16 -- 17

larval central nervous system | faint

(Park et al., 2011)

Additional Descriptive Data

mael transcript is expressed at a weak to moderate level in the CNS of late stage embryos. mael transcript is also expressed in dimm-positive neurons in adults.

(Park et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

somatic cell of ovariole of germarium

(Minakhina et al., 2014)

adult stage | female & oogenesis

germarium & germline cell

(Clegg et al., 1997)

oogenesis & adult stage | female

female germline cell of germarium

(Minakhina et al., 2014)

adult stage oogenesis stage S1 -- S8

(Clegg et al., 1997)

Additional Descriptive Data

During oogenesis, mael protein is detected in a punctate pattern in germ line cells throughout the germarium, including those in germarium region 1. Expression is uniform in nurse cells and oocytes in early egg chambers, but by stage S5, it is strongest around the periphery of cells. Protein accumulation decreases in stages S5 and S6, especially in the oocyte. No mael protein is detected after stage S8.

(Clegg et al., 1997)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Sienski et al., 2015, Findley et al., 2003)

located_in nucleus

inferred from direct assay

(Pek et al., 2009)

inferred from direct assay

(Findley et al., 2003)

is_active_in P granule

inferred from direct assay

(Huang et al., 2014)

located_in P granule

inferred from direct assay

(Patil and Kai, 2010, Findley et al., 2003)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Lim and Kai, 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mael in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mael

View exonic expression by tissue for Dmel\mael

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016034

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40489/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016034

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016034

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016034

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11254

Flygut - An atlas of the Drosophila adult midgut

FBgn0016034

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\mael

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mael

Transgenic constructs containing regulatory region of mael

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Clegg et al., 1997)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage | recessive

mael^r15

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mael^GD7254

viable, with Scer\GAL4^Mef2.PR

mael^GD7254

viable, with Scer\GAL4^pnr-MD237

mael^GD7254

viable, with Scer\GAL4^tin.CΔ4

mael^GD7254

Sterility

Allele

female semi-sterile, with Scer\GAL4^nanos.PG

mael^KK106194

female sterile, with Scer\GAL4^nanos.PG

mael^GL00077

female sterile (with Df(3L)79E-F)

mael^M391

male sterile (with Df(3L)79E-F)

mael^M391

sterile (with Df(3L)79E-F)

mael^M391

Other Phenotypes

Allele

abnormal cell number | male

mael^M391

some die during embryonic stage | recessive

mael^r15

mael^+t4.5

Phenotype manifest in

Allele

cystoblast | increased number (with Df(3L)79E-F)

mael^M391

dorsal appendage

mael^r20

dorsal appendage | germline clone | maternal effect

mael^sat

egg chorion | germline clone

mael^r20

female germline stem cell | increased number (with Df(3L)79E-F)

mael^M391

mael^r20

germarium region 3 (with Df(3L)79E-F)

mael^M391

mael^M391

mael^M391

male germline cell (with Df(3L)79E-F)

mael^M391

male germline cyst (with Df(3L)79E-F)

mael^M391

male germline stem cell | ectopic (with Df(3L)79E-F)

mael^M391

microtubule & oocyte

oocyte & centriole (with Df(3L)79E-F)

mael^r20

oocyte & microtubule

mael^unspecified

oocyte & microtubule organizing center (with Df(3L)79E-F)

mael^r20

oocyte | germline clone

mael^r20

mael^M391

spermatocyte ring canal (with Df(3L)79E-F)

mael^M391

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

12 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

13 of 14

Yes

Yes

Mus musculus (laboratory mouse) (1)

12 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (2)

10 of 13

Yes

Yes

1 of 13

No

Yes

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP002022

12 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mael. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MAEL; maelstrom spermatogenic transposon silencer

12 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sato et al., 2011)

anti bait coimmunoprecipitation, western blot

(Murano et al., 2019)

anti tag coimmunoprecipitation, anti tag western blot, pull down, Identification by mass spectrometry

(Ninova et al., 2023)

anti bait coimmunoprecipitation, western blot

(Minakhina et al., 2014)

anti tag coimmunoprecipitation, western blot

(Onishi et al., 2020)

anti bait coimmunoprecipitation, western blot, genetic interference, peptide massfingerprinting

(Sato et al., 2011)

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Sato et al., 2011)

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sato et al., 2011)

anti tag coimmunoprecipitation, western blot

(Murano et al., 2019)

anti bait coimmunoprecipitation, anti tag western blot, western blot

(Onishi et al., 2020)

anti tag coimmunoprecipitation, anti tag western blot

(Pek et al., 2012)

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sato et al., 2011)

anti bait coimmunoprecipitation, peptide massfingerprinting, western blot

(Sato et al., 2011)

mael - γTub23C

anti bait coimmunoprecipitation, western blot

(Sato et al., 2011)

mael - γTub37C

anti bait coimmunoprecipitation, western blot

(Sato et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Pek et al., 2009)

suppressible

(Pek et al., 2009)

enhanceable

(Hayashi et al., 2014)

suppressible

(Pek et al., 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Hayashi et al., 2014)

suppressible

(Pek et al., 2012)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65723

DroID - A comprehensive database of gene and protein interactions.

FBgn0016034

MIST (genetic) - An integrated Molecular Interaction Database

40489

MIST (protein-protein) - An integrated Molecular Interaction Database

40489

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-47

Cytogenetic map

Sequence location

3L:22,721,203..22,726,234 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

80A1-80A1

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

79E-79E

(Clegg, 1997.9.18)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

8516

w^*; mael^r20/TM3, Sb¹

63304

w¹¹¹⁸; PBac{IT.GAL4}mael^0419-G4

16006

y¹ w^67c23; P{EPgy2}mael^EY08554

35202

y¹ sc^* v¹ sev²¹; P{TRiP.GL00077}attP2

34793

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00102}attP2

13015

y¹; P{SUPor-P}KG03309b P{SUPor-P}mael^KG03309a ry⁵⁰⁶

11254R-1

GL00077

y¹ sc^* v¹ sev²¹; P{TRiP.GL00077}attP2

v100907

P{KK106194}VIE-260B

v18198

w¹¹¹⁸; P{GD7254}v18198

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (45)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD20229

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0016034

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0016034

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Na et al., 2016, Sato et al., 2011)

polyclonal

(Huang et al., 2014, Sienski et al., 2012, Pek et al., 2009, Clegg et al., 1997)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

mael is required for proper differentiation in the germline stem cell lineage in males.

(Pek et al., 2009)

mael is required in the germline for proper reorientation of the oocyte cytoskeleton in response to signalling from the surrounding follicular epithelium.

(Bryant et al., 1997)

Mutations in mael transform posterior follicle cells into anterior fates.

(Clegg et al., 1997)

mael acts in the germline after follicle cell determination to organise the oocyte cytoskeleton.

(Clegg et al., 1997)

mael function is required in the germline for correct posterior localisation of a variety of transcripts in early oocytes, including grk mRNA. Posterior localisation of grk mRNA in the early oocyte is essential for proper A/P axis formation.

(Clegg et al., 1997)

Mutations reveal a novel step in mRNA localisation within the oocyte. Mutants disrupt the normal assymetric distribution of markers along the A/P axis and they disrupt the microtubule-dependent migration of the oocyte nucleus.

(Clegg et al., 1997)

Required for the localization of morphogens and for the correct formation of the cytoskeleton in oocytes.

(Ruohola-Baker et al., 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: mael CG11254

(Beasley, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG11254

(Na et al., 2016, Ni et al., 2011.7.19, Park et al., 2011, Keleman et al., 2009.8.5, Brandt, 2006)

MAEL

(Gamez et al., 2020, Kolaczkowski et al., 2011, Janic et al., 2010)

mae1

(Domazet-Loso and Tautz, 2003)

mael

(Fitz-James et al., 2025, Baumgartner, 2024, Lécureuil et al., 2021, Ellison et al., 2020, Onishi et al., 2020, Saint-Leandre et al., 2020, Chang et al., 2019, Kolliopoulou et al., 2019, Story et al., 2019, Kang et al., 2018, Karaiskos et al., 2017, Teixeira et al., 2017, Blumenstiel et al., 2016, Clandinin and Owens, 2016-, Na et al., 2016, Dufourt et al., 2014, Hayashi et al., 2014, Minakhina et al., 2014, Patil et al., 2014, Yan et al., 2014, Czech et al., 2013, Dönertas et al., 2013, Handler et al., 2013, Muerdter et al., 2013, Anand and Kai, 2012, Japanese National Institute of Genetics, 2012.5.21, Pek et al., 2012, Sienski et al., 2012, Vazquez-Pianzola and Suter, 2012, Klenov et al., 2011, Park et al., 2011, Sato et al., 2011, Tchurikov and Kretova, 2011, Tiwari et al., 2011, Anne, 2010, Nagao et al., 2010, Orsi et al., 2010, Patil and Kai, 2010, Saito et al., 2010, Navarro et al., 2009, Pek et al., 2009, Anne et al., 2007, Lim and Kai, 2007, Lim and Kai, 2007, Brandt, 2006, Liebl et al., 2006, Ferree et al., 2005)

Name Synonyms

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40489

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VNS0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VNS0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0S0WNT6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VNS0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016034

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40489/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016034

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016034

FlyMine - An integrated database for Drosophila genomics

FBgn0016034

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11254

MARRVEL_MODEL - MARRVEL (model organism gene)

40489

PDB - An information portal to biological macromolecular structures

4YBG

Linkouts

BioGRID - A database of protein and genetic interactions.

65723

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0016034

DroID - A comprehensive database of gene and protein interactions.

FBgn0016034

DRSC - Results frm RNAi screens

FBgn0016034

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016034

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0016034

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11254

Flygut - An atlas of the Drosophila adult midgut

FBgn0016034

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008172

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

40489

MIST (protein-protein) - An integrated Molecular Interaction Database

40489

References (145)