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General Information
Symbol
Dmel\AGO3t3
Species
D. melanogaster
Name
FlyBase ID
FBal0239064
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G23569528A

Amino acid change:

W452term | AGO3-PD; W452term | AGO3-PE; W452term | AGO3-PF; W452term | AGO3-PG

Reported amino acid change:

W452term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W452term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

AGO3t2/AGO3t3 females are sterile, initially laying far fewer eggs than their control siblings and stopping laying altogether by stage 10. None of the eggs laid by these females hatch and many of them have fused or missing dorsal appendages.

AGO3t2/AGO3t3 males are semifertile, siring fewer offspring than do control males with the same genetic background. Ste protein crystals form in primary spermatocytes in AGO3t2/AGO3t3 testes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference

AGO3t3 is a non-suppressor of neoplasia phenotype of l(3)mbtts1

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The frequency with which l(3)mbtts1 larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) is not significantly altered if the transplanted tissue is also homozygous for AGO3t3.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (14)